2 / 11
Page 30
Notes:
3
rd
International Conference on
Health Care and
Health Management
Joint Event
&
November 04-05, 2019 | Prague, Czech Republic
6
th
International Conference on
Neuroscience and
Neurological Disorders
Journal of Neurology and Clinical Neuroscience | Volume 3
Inhibitory vs exhibitory neuron factors - How the balance of conductive forces needs to be
seen at a base level
Paul Lang
Epilepsy Connection Affiliated, Australia
Introduction:
This presentation will be focussing on how
the core differences between our 2 major neuron types –
Inhibitory & Exhibitory – play a major role in the balance
which controls seizures. I will be discussing the original
medical views on the matter, then how views changed
once technology gave us greater insight into electrical
activity within the brain – and finalise by relating current
research to a very understandable analogy such as taste
and sound to give the presentation a much wider audience
scope.
Description:
“Humans have between 90 & 170 different
“types” of Neurons (depending on how you classify sub-
categories) but they all actually fall into 2 categories –
Inhibitory vs Exhibitory. This effectively means the signal
that neuron sends out either generates more (exhibitory)
or less (inhibitory) reactionary signals from the surrounding
neurons. So basically, some neurons will generate more
activity from the neurons around them – whereas others will
cause the neurons around them to generate less activity. Prior
Neurological studies into Epilepsy focussed mainly on the
accelerant (Exhibitory) factor – that flaring was only caused
by an increase in electrical activity. But we have found this
is not correct. It is actually a balancing act that involves the
complex processes of ion gating channels combined MRNA
signals vs enzyme and protein regulation and charged ion
volumes staying at a steady rate that does not activate the
flaring process. And that’s just a simplified view of the issue
to say the least.
A key factor wewill be looking at is the role genetic signals play
in ion gating channels that effect electrical conduction. Studies
into SCN2A sodium regulation gene, CaMk11 enzyme, CNTN2
potassium regulators, PKD2 regulators, CRAC regulators,
EAG2 potassium channels, MRNA Sodium channel regulators
and Reelin gene will be discussed as part of the presentation.
Speaker Biography
Paul Lang is the Founder and CEO of ECA. Having been diagnosed with
a rare form of Epilepsy himself at age 19. He took a lifelong interest in
the condition and Neurology itself. After spending much of his adult life
researching his own condition, he founded the charity ECA to help spread
awareness about Epilepsy - but also support the work being done by
charities & research organisations worldwide. Currently his foundation
works with organisations from all over the world and ECA is the largest free
global affiliate for Epilepsy charity services currently operating. He works
constantly as an advocate for research and the expansion of other charities
worldwide – collaborating constantly with other global organisations on
worldwide campaigns & international conferences.
e:
info@epcona.org