neurosurgery-neuroimmunology-2019-scientifictracks

Page 18

Notes:

Volume 3

Journal of Neurology and Clinical Neuroscience

Neurosurgery 2019 & Neuroimmunology 2019

May 22-23, 2019

Neurosurgery and Neurological Surgeons

Neuroscience and Neuroimmunology

May 22-23, 2019 London, UK

Annual Meeting on

Global Summit on

J Neurol Clin Neurosci, Volume 3

Correlation of ubiquitin c terminal hydrolase and s100β in predicting deficits in

cognitive control in young adults with mild traumatic brain injury

Subir dey

Command Hospital Lucknow, India

Objective:

To study the acute phase serum biomarkers in patients with mild traumatic brain injury (mTBI) and to correlate them

with short term cognitive deficits.

Materials and Methods:

This is a prospective observational study conducted at a tertiary care center for neurotrauma. The

participants included patients with mTBI (n = 20) and age, gender, and education-status matched healthy controls (n = 20). In

both the groups, the serum concentrations of biomarkers ubiquitin C terminal hydrolase (UCH-L1) and S100 calcium-binding

protein B (S100B) were measured. Both the groups underwent neuropsychological tests. The serum tests were done in the acute

stage after injury and the neuropsychological tests were done 3 months after injury.

Results:

There was no significant increase in the serum S100B and UCH-L1 levels in patients with mTBI. Patients with mTBI

had significant cognitive deficits at 3 months after injury, which was suggestive of involvement of diffuse areas of the brain, in

particular, the premotor, prefrontal, and medial inferior frontal lobes and the basitemporal region. The correlation of biomarkers

with cognitive deficits in patients with mTBI was found in the following domains: working memory, verbal learning, verbal

fluency, and visual memory.

Conclusion:

The serum biomarkers of mTBI have a correlation with selective domains of neuropsychological outcome.

Biography

Subir Dey is heading the department of neurosurgery at Command Hospital Lucknow, India. He has done his graduation and post-

graduation from Armed Forces Medical College. Later he did his Mch from NIMHANS, Bangalore. He has a keen interest in the

Neurotrauma and Rehabilitation of Indian soldiers their relatives and veterans. It gives him immense pleasure to see and treat or

operate the head injury individuals who come in comatose condition and go on their foot walking. He is instrumental in designing the

neurorehabilitation programme at our centre.