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Volume 1, Issue 1
J Nurs Res Pract
Nursing Care & Breast Congress 2017
December 11-13, 2017
December 11-13, 2017 | Rome, Italy
Joint Event
&
45
th
WORLD CONGRESS ON NURSING CARE
8
TH
EUROPEAN BREAST CONGRESS
Does mammographic density in women with previous breast cancer predict further breast cancer?
Shuk Yee Choo
Kings College Hospital NHS Foundation Trust, UK
Background:
The aim of this research was to determine whether increased mammographic density in women with a previously
diagnosed breast cancer is related to the risk of development or detection of a further breast cancer in either breast.
Methods:
906 women with previous breast cancer were identified from those consenting to the Predicting Risk of Cancer at
Screening (PROCAS) study. Personal risk factors were self-reported, with visual assessment of mammographic density recorded
by two readers on Visual Analogue Scales (VAS) and automated volumetric breast density measured using VolparaTM. Of
these women, 23 had a subsequent contralateral breast cancer and 17 had subsequent ipsilateral breast cancer. A nested case
control study was carried out where cases were women with a second breast cancer. Three controls per case were matched on
age, HRT use, menopausal status, parity and BMI.
Results:
Increased dense volume in the breast contralateral to that of the previous cancer was associated with subsequent
development of cancer in that breast, with median fibroglandular volumes of 44.8 and 37.9 cm3 respectively (p<0.05) for cases
and controls, although no significant difference between cases and controls was found for volumetric or visually assessed
percent density. No association between increased mammographic density and a second ipsilateral breast cancer was found.
Discussion:
Our results suggest that increased fibroglandular volume might be predictive of subsequent contralateral breast
cancers in women with a previous diagnosis of breast cancer, but further investigation with a larger sample size is needed to
confirm this result.
shukyee.choo@nhs.netShuk Yee Choo, J Nurs Res Pract 2017, 1:1(Suppl)