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Volume 1, Issue 1 J Nurs Res Pract Nursing Care & Breast Congress 2017
December 11-13, 2017
December 11-13, 2017 | Rome, Italy
Joint Event
&
45th WORLD CONGRESS ON NURSING CARE
8TH EUROPEAN BREAST CONGRESS
The effect of vitamin D supplementation on breast density changes: A clinical trial study
Sadaf Alipour1,2, Azin Saberi2, Leila Bayani2, Nooshin Shirzad3,4, Mahdi Sepidarkish5 and Ladan Hosseini2
1Vali-e-Asr Reproduction Health Research Center, TUMS, Iran
2Arash Women’s Hospital, Tehran, Iran
3EMRI-TUMS, Iran
4Valiasr Hospital, TUMS, Iran
5Royan Institute for Reproductive Biomedicine - ACECR, Iran
Background: Previous evidence suggests that vitamin D reduces the incidence and mortality of breast cancer. The aim of this
study was to determine the effect of supplementation with 50,000 IU/monthly vitamin D for one year on breast density in
Iranian women.
Methods: This double-blind, placebo-controlled, single center clinical trial was conducted among 500 women aged 40 years
and older. Participants were allocated to two groups. Group 1 received vitamin D 50,000 IU in tablet form, monthly, for one
year. Group 2 received vitamin E 400 IU in tablet form, for the same period of time. Participants had follow up clinic visits
every six months and received an annual mammogram.
Results: Final data were evaluated based on 216 and 194 women in the treatment and control groups. The mean decrease in
mammographic density was -5.01% (95% CI, -9.9% to -0.01%) and -2.34%(95% CI, -6.84% to -2.15%) in the treatment and
control groups, respectively. There was no significant association between vitamin D consumption and breast density after
one year (OR=0.7, 95% CI, 0.46 to 1.06; P=0.1). Similar results were observed when multivariate model of logistic regression
analysis was performed and vitamin D consumption was not significantly associated with breast density, independent of other
variables (OR=1.07.95% CI, 0.58 to 1.96; P=0.8).
Discussion: This study showed that monthly consumption of 50,000 IU of vitamin D supplementation for one year did not
effect on breast density.
Biography
Sadaf Alipour , MD , Cancer Surgeon, Breast Surgeon was an Associate professor in Surgery in Arash Women’s Hospital, Tehran University of Medical Sciences.
She is interested in the Field of Breast Cancer, Breast Surgery.
Sadaf Alipour et al., J Nurs Res Pract 2017, 1:1(Suppl)