nursing-care-breast-congress-2017-scientifictracks

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Volume 1, Issue 1

J Nurs Res Pract

Nursing Care & Breast Congress 2017

December 11-13, 2017

December 11-13, 2017 | Rome, Italy

Joint Event

WORLD CONGRESS ON NURSING CARE

EUROPEAN BREAST CONGRESS

Does Mode of surgical intervention based on Oncotype DX Score influence disease recurrence in

early breast cancer? A Pilot study

Aherne Thomas M, Catargiu D, Bashar K, Sugrue R, McVeigh T, Brodie C

and

Sweeney KJ

University Hospital Galway, Ireland

Introduction:

Routine utilization of multi gene assays to inform operative decision making in early breast cancer (EBC)

Treatment is yet to be established. In This pilot study we sought to establish the potential benefits of surgical intervention in

EBC Based on recurrence risk quantification using the oncotype DX (ODX) assay.

Materials and Methods:

Consecutive ODX Tests performed over a nine year period from October 2007 To May 2016 were

evaluated. Oncotype Scores were classified into high (≥31), medium (18-30) Or low risk(0-17) groups. The Primary outcome

was breast cancer recurrence. Subgroup Analysis was utilized to assess the recurrence effect of mode of surgical intervention

for patient groups as defined by the oncotype score.

Results:

In Total 361 Patients underwent ODX testing. The Mean age and follow up was 55 Years and 38.9 months. The

Majority of patients underwent wide local excision (86.7%) with 8.9% and 4.4% patients having a mastectomy or WLE with

completion mastectomy respectively. Fifty one Percent of patients fell into the low risk ODX Category with a further 40.2%

and 8.5% Deemed to be of intermediate and high risk. Five Patients (1.38%) had disease recurrence. Comparative Analysis

of operative groups in each oncotype group revealed no difference in recurrence in the Low (p=0.84) and high risk groups

(p=0.92) with a statistically significant difference identified in the intermediate risk group (p=0.002).

Discussion:

To Date we have been unable to definitively identify a role for ODX In guiding surgical approach in EBC. There is,

however, a need for larger well designed studies to examine this hypothesis.

Aherne Thomas M et al., J Nurs Res Pract 2017, 1:1(Suppl)