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Volume 3
Journal of Nursing Research and Practice
Nursing & Immunology 2019
March 11-12, 2019
Neonatology, Pediatric Nursing and Nursing
Immunology
March 11-12, 2019 London, UK
World Congress on
8
th
World Congress on
&
Basic metabolic disorders in children with diabetic nephropathy
Ievgeniia Burlaka
National O O Bogomolets Medical University, Ukraine
Introduction:
The increased prevalence of Type I Diabetes (T1D) has also led to an increase in the number of macro- and
microvascular complications of diabetes such as coronary heart disease, stroke, visual impairment, Diabetic Nephropathy (DN), and
End Stage Renal Disease (ESRD). Additionally, diabetes remains the most common reason for progressing to ESRD.
Aim:
to study the levels of basic metabolic disorders in children with T1D and at diabetic nephropathy.
Material and methods:
26 children I0–16 years old with T1D and diabetic nephropathy examined. An affinity of hemoglobin
to oxygen and oxidation of lipids detected using the method of spectrophotometry. The levels of cellular hypoxia marker HIF-1
measured using Western Blotting method.
Results:
In the group of children with the firstly diagnosed T1D high level of dissociation of hemoglobin and oxygen as compared
to control group detected. In the group of children with developed diabetic nephropathy the level of marker was considerably lower
than in control group and patients with T1D. High level of intracellular hypoxia evaluated in all patients comparing with the control.
HIF-1 level considerably higher in patients with nephropathy than in children with T1D. An increase of lipids oxidation coefficient
depending on the level of compensation of T1D.
Discussion:
We have studied the key indicators of basic metabolic and hypoxic disorders in childern with T1D and patients with
diabetic nephropathy. Further study of these markers and its interdependence in the network of disorders caused by the deficiency
of vitamin D3 and disorders in system of apoptosis control especially in aspect of diabetic nephropathy progressing is a promising
direction of prophylaxis schemes creation and diabetic nephropathy treatment
evgbur1982@gmail.comJ Nursing Research and Practice, Volume 3
DOI: 10.4172/2632-251X-C1-003