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Nutraceuticals 2019
July 15-16, 2019
Volume 2
Journal of Food and Clinical Nutrition
Advanced Nutraceuticals and Functional Foods
July 15-16, 2019 | London, UK
World Congress on
J Food Clin Nutr, Volume 2
Pilot and pivotal clinical outcome study to determine satiation and satiety through
Fenulean (Fenugreek flakes) administered on healthy volunteers with > 30 BMI. Possible
mechanism of action?
Krathish Bopanna
Consultant Pharmacologist, India
F
enuLean (Fenugreek flakes) is a proprietary product of Bio-gen Extracts Ltd. was de-fatted and de-bitterized fibres
with a high fibre content of ≥ 50% of which 20-25% are soluble fibres and 30-35% are insoluble fibres. The bulking
and viscosity properties of dietary fibre in the stomach are predominantly responsible for influencing satiation and
satiety which in turn are the key indicators in the weight management program. In the pilot and pivotal study conducted
FenuLean, taken thirty minutes prior to meal, effectively suppress the appetite by initiating the sense of satiety, reduction
of hunger, feeling of fullness, desire to consume food and prospective need to consume food. Fibre rich foods usually are
accompanied by increased efforts and/or time of mastication, which leads to increased satiety through a reduction in rate
of ingestion. It makes a good replacement for conventional products in number of bakery items.
Interestingly soluble fibre derived from FenuLean has been identified chemically as galactomannans just like other
fibre of guar seeds or psyllium husk. Interestingly the ratio of mannose to galactose in the FenuLean is 1:1 making it
superior in terms of its gel-forming characteristic over other galactomannans. Interestingly we found changes in the
post prandial glucose response and this could be attributed to the increasing the viscosity of digested food in the gut,
these fibres, especially of fenugreek origin, delay the absorption of carbohydrates. Considering the significant amounts
of galactomannans in fenugreek seeds, it is of utmost importance that the effects of these in the control of postprandial
glycemia and its response to weight management. Our studies using FenuLean showed growing evidence in the literature
that fenugreek fibres can improve glucose homeostasis by delaying carbohydrate digestion and absorption and enhancing
insulin action.
Primary aim of our study was to examine the effects of FenuLean from fenugreek at 10g and 5g on satiety and fullness,
and on reduced ratings of hunger, desire and prospective food consumption. Secondary objective was to determine
FenuLean at the same doses from fenugreek would reduce glycemic and insulin response apart from the palatability. The
Investigational Product (IP) contained FenuLean 5g and 10g. FenuLean 5g / 10g was consumed orally with water along
with a standard meal (breakfast).
FenuLean 5g & 10g consumption lead to improvement in
• Overall satiety of the healthy subjects
• Increased satisfied satiety and higher fullness was observed
• Reduced hunger, desire to consume food and prospective food consumption
• Satiety satisfaction and fullness scores increased from thirty minutes post consumption
• Positive trend of reduction in serum insulin after consumption
• Overall, palatability of the FenuLean 5g and 10g was found to be comparable.