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November 11-12, 2019 | London, UK
TOXICOLOGY AND CLINICAL TOXICOLOGY
2nd International Conference on
Clin Pharmacol Toxicol Res, Volume 02
Volume 02
Clinical Pharmacology and Toxicology Research Toxicology 2019
November 11-12, 2019
Clinical and experimental data on Diphoterine solution decontamination of eye/skin
chemical exposures
Diphoterine is an amphoteric, slightly hypertonic, polyvalent, sterile water-based eye/skin decontamination solution which
combines passive flushing with active chemical decontamination. Reviews were published in French (Minaro et al, 2000)
and Hall et al (2002). Since that time, many more studies of Diphoterine safety and efficacy, both pre-clinical and clinical, have
been performed. This review describes earlier studies and details more current ones. Some of these were described in reviews
at the Medichem Conference, Basel, Switzerland, 2016, at the AMPAT Congress, Singapore, 2016, and the AOHC Congress,
Kaohsiung, Taiwan. Presented here are new not previously presented data.
Materials and Methods: A review of all new data since previous presentations was performed.
Results: Non-Clinical: In vitro/ex vivo comparative decontamination studies with phenol (acid) and tetraammonium hydroxide
(TMAH) (base) have been performed. In both cases, Diphoterine solution decontaminationwas superior towater decontamination.
Clinical studies have included a 20-year chemically-exposed eye study from Germany in which Diphoterine solution was found
better than any other rinsing solution.Amulti-center, multinational clinical study from France and Belgium showed the efficacy of
Diphoterine solution for decontamination of chemically-exposed skin, eyes and oral membranes in the pre-hospital and emergency
department settings. Similar results were found in a clinical study of occupational phenol exposure outcomes in Taiwan and
exposure to various various caustic substances in India.
Conclusion: Based on previously published/presented data and data presented here, Diphoterine solution is a better choice than
potable water or other rinsing solutions for first aid, pre-hospital and emergency department (even if delayed) decontamination of
chemical eye/skin exposures.
Biography
Alan H Hall, M.D. is a board certified Medical Toxicologist and is President and Chief Medical Toxicologist of Toxicology Consulting and
Medical Translating Services, Inc., Laramie, Wyoming. He is also Clinical Assistant Professor at the Colorado School of Public Health,
Denver, Colorado and was formerly Clinical Assistant Professor of Preventive Medicine and Biometrics at the University of Colorado School
of Medicine and Assistant Professor of Pediatrics. Dr. Hall was formerly Research Assistant Professor in the Division of Medical Toxicology,
Department of Emergency Medicine, Texas Tech University Health Sciences Center, El Paso, Texas. He received his undergraduate degree
from Indiana University South Bend, South Bend, Indiana from which university he has Division and University-wide Distinguished Alumnus
awards. He received his Doctor of Medicine degree from the Indiana University School of Medicine, Indianapolis, Indiana. Dr. Hall has been
in General Practice, trained in Anesthesiology and practiced Occupational and Environmental Medicine and Emergency Medicine.
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Laurence Mathieu is the head of the scientific action Group of PREVOR Laboratory. She is an engineer in chemistry and she has a PhD
in organic Chemistry. Her research interests are decontamination of chemical exposures (eye, skin, skin carcinogenesis, digestive burns,
inhalation) and chemical spills, dermonecrosis due to venoms (spiders, snakes, jellywash) in wound healing and scarring.
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Alan H Hall
University of Colorado Denver, USA
Laurence Mathieu
Laboratoire Prevor, France