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Volume 3
Journal of Reproductive Biology and Endocrinology
WCGO2019
May 13-14 , 2019
Page 11
Gynecology and Obstetrics
May 13-14 , 2019 Tokyo, Japan
2
nd
World Congress on
J Reprod Biol Endocrinol, Volume 3
Clinical experience with synthetic osmotic dilators in cervical preparation to abortion
Introduction:
Reducing maternal morbidity and mortality related to pregnancy termination is one of
the main objectives of female reproductive health preservation. Cervical preparation is an important
aspect of safe abortion practice. Forceful cervical dilatation increases the risk of traumas, hemorrhages,
and other complications. Thus, the searching of safe methods of cervical preparation remains relevant.
Dilapan-S is a hygroscopic cervical dilator, which does not contain any pharmacological agents. The
aim of our study is to assess the results of pregnancy termination in the second trimester using synthetic
osmotic dilators.
Materials and methods:
The study included 216 women who had medical pregnancy termination in the
second trimester in gestational age over 12 and up to 21 weeks 6 days. Group 1 included 135 patients who
underwent medical abortion. Surgical abortion was performed in group 2 (n=81). Three Dilapan-S for
nulliparous women and four for parous women provided sufficient cervical preparation. In group 1, we
used two doses of sublingual misoprostol (400 microg) in 4hour intervals after removing of Dilapan-S.
The mean duration of cervical preparation by Dilapan-S was 12±0.5 hours.
Results:
The interval between the misoprostol intake and pregnancy termination in group 1 averaged
8.8±0.5 hours: 9.5±0.8 hours in nulliparous and 7.8±0.6 hours in multiparous. In group 2, neither woman
required additional mechanical dilatation. There were no difficulties associated with the insertion of
Dilapan-S in any of the patients. Infectious or inflammatory complications have not been recorded in
any of the patients both in the early and late post-termination period.
Conclusion:
The additional use of Dilapan-S for cervical preparation allows for faster pregnancy
termination and reduces the length of hospital stay without increasing complications rate and side effects.
Biography
Natalia Kan MD, PhD, Professor of the Department of obstetrics, gynecology and perinatology of the Federal State Budget Institution
«National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov» of the Minis-
try of healthcare of the Russian Federation. Head of the obstetric scientific schools of the Federal State Budget Institution «Nation-
al Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov» of the Ministry of
healthcare of the Russian Federation Chief physician of Perinatal Center of European Medical Center, Moscow, Russian Federation
kan-med@mail.ru.
Natalia Kan
European Medical Center, Russia