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Volume 2 Journal of Molecular Cancer Breast Cancer & Vascular Conference 2019
February 25-26, 2019
February 25-26, 2019 London, UK
Joint event on
World Congress on Breast Cancer
Vascular Biology & Surgeons Meeting
5th International Conference on
&
Network pharmacology-based discovery of natural and herbal anti-inflammatory agents co-targeting
ischemic brain and heart diseases
Yan Zhu
Tianjin University, China
Although stroke and coronary artery disease (CAD) are different diseases, both preclinical and clinical evidence have suggested their
intricate connections, some of which mediated by inflammation and immune response. Recent Canakinumab Anti-inflammatory
Thrombosis Outcome Study (CANTOS) trial demonstrated the effects of IL-1β neutralizing antibody in atherosclerosis, providing the
first convincing proof that modulating inflammation improves patients’ cardiovascular health, and launches the era of immunotherapy
in CAD. Herbal medicine has been a rich source for CAD drugs and also has great potential for the discovery of novel anti-inflammatory
and immune-modulating agents. We present an integrated strategy using network pharmacology/transcriptome analyses followed by
cell-based and in vivo experimental validation to decipher common and differential pharmacological mechanisms of herbal medicine
formulae on stoke and CAD treatment. Examples of using this approach to systematically identify multiple active components from
Radix Salviae miltiorrhizae, Flos Carthami tinctorii and Ginkgo biloba co-targeting the brain and heart diseases and revealing their
unique anti-inflammatory mechanisms, will be discussed.
J Molecular Cancer
Volume 2