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Volume 04
Current Research: Integrative Medicine
Curr Res Integr Med, Volume 04, ISSN: 2529-797X
December 02-03, 2019 | Dubai, UAE
CAM Therapies 2019
December 02-03, 2019
World Congress on
Complementary and Alternative Medicine
Natural product based anti-atherosclerotic therapy
Alexander N Orekhov
Institute of General Pathology and Pathophysiology, Russia
A
therosclerosis is the cause of more than 50% mortality in industrial countries. Atherosclerosis develops over many years, so
the anti-atherosclerotic therapy should be long-term or even lifelong. Tachyphylaxis, long-term toxicity and cost amongst
other issues may present problems for the use of conventional medications in the long-term. Drugs based on natural products
can be a good alternative.
We have developed a series of natural compounds that are specifically designed to act at the vessel wall and modulate the
atherosclerotic lesion. Clinical efficacy was determined in atherosclerosis regression studies with ultrasound examination of
carotid arteries.
The AMAR study (Atherosclerosis Monitoring and Atherogenicity Reduction) was designed to estimate the effect of two-year
treatment with time-released garlic-based drug Allicor on the progression of carotid atherosclerosis in asymptomatic men in
double-blinded placebo-controlled randomized clinical trial. The primary outcome was the rate of atherosclerosis progression,
measured by high-resolution B-mode ultrasonography as the increase in carotid Intima Media Thickness (IMT) of the far wall
of common carotid arteries. The mean rate of IMT changes in Allicor-treated group was significantly different from the placebo
group in which there was moderate progression. The results of AMAR study demonstrate that long-term treatment with Allicor
has a direct anti-atherosclerotic effect on carotid atherosclerosis. These results encouraged clinical trials of two other drugs based
on natural products, including: Inflaminat (calendula, elder and violet), possessing anti-cytokine activity and the phytoestrogen-
rich drug Karinat (garlic powder, extract of grape seeds, green tea leafs, hop cones, β-carotene, α-tocopherol and ascorbic acid),
designed for postmenopausal women. As in the AMAR trial Inflaminat caused regression of carotid atherosclerosis while Karinat
prevented its development.
As a promising anti-atherosclerotic drug, we consider natural products that can inhibit sialidase activity. It was discovered that
atherogenic modified low-density lipoprotein with low sialic acid levels circulates in the blood of atherosclerotic patients. The
desialylation of lipoprotein particles is the key atherogenic modification that causes the accumulation of cholesterol in arterial
cells. We developed two garlic-based and pollen-based drugs that inhibit sialidase activity in the blood.
It should be noted that the anti-atherosclerotic effects of drugs based on natural products are not inferior to the effects of such
drugs as statins and calcium antagonists. Thus, natural products can be considered as promising drugs for anti-atherosclerotic
therapy.
a.h.opexob@gmail.com