2 / 7
Page 18
Volume 2
Journal of Molecular Cancer
Cancer & Primary Healthcare 2019
May 20-21, 2019
Cancer Research & Oncology
Primary Healthcare and Medicare Summit
May 20-21, 2019 | Rome, Italy
25
th
Global Meet on
World Congress on
&
The crucial role of CHI3L1 in vasculogenic mimicry formation of cervical cancer
Nipaporn Ngernyuang
Thammasat University, Thailand
Statement of the problem:
Over the past several decades, accumulating evidence has revealed that highly
metastatic cancers are intimately associated with vessel-like formation that is primarily derived from tumor
cells, independent of endothelial cell-mediated angiogenesis. This alternative microvascular formation
lacking endothelial cells is known as vasculogenic mimicry (VM). VM develops tumor vascular networks
that associated tumor growth, metastasis, and short survival time of cancer patients. However, the knowledge
of VM in the vascularization of cervical cancer are not fully understood yet. Chitinase-3-like-1 (CHI3L1)
has been reported to plays a critical role in angiogenesis of cervical cancer. Here, we explored a pathological
function of CHI3L1 in tumor cell-mediated vascularization.
Methodology & Theoretical orientation:
The sixty- six tissue samples of cervical cancer were collected to
determine CHI3L1 expression and VM formation using immunohistochemistry and CD34-periodic acid-
Schiff (PAS) dual staining.
Findings:
CHI3L1 expression was significantly correlated with VM formation (p = 0.031). Interestingly,
patients with VM positive tumors tended to have decreased overall survival (OS) compared to those with VM
negative samples (43.9 versus 64.6 months, p = 0.079). In addition, recombinant CHI3L1 enhanced cervical
cancer cell lines to form tube-like structures, supporting the notion that CHI3L1 mediates VM in cervical
cancer. Conclusion & Significance: Our present findings suggest the crucial role of CHI3L1 by promoting the
formation, which may contribute to tumor aggressiveness. Therefore, CHI3L1 may represent a novel attractive
therapeutic target for the reduction of cervical cancer vascularization and metastasis.
Biography
Nipaporn Ngernyuang has completed her Ph.D. in Biomedical sciences from Khon Khan University, Thailand. Currently, she is an
Assistant Professor at Chulabhorn International College of Medicine, Thammasat University, Thailand. Her program of research
focuses on molecular oncology and nanotechnology for cancer treatment. She has published about 8 papers in reputed journals. She
has received researcher awards for her scholarly work from Thammasat University.
nngernyuang@gmail.comJ Mol Cancer, Volume 2