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Volume 5
Journal of Current Research: Cardiology
Heart Congress 2018
November 21-22, 2018
2
nd
Global Heart Congress
November 21-22, 2018 Osaka, Japan
Value of global longitudinal peak systolic strain derived by 2D speckle tracking in detection of obstructive
coronary artery disease
Mohamed Fayez
Mansoura University, Egypt
Background & Aim:
Non-invasive identification of patients with Coronary Artery Disease (CAD) remains a clinical challenge
despite the widespread use of imaging and provocative tests and speckle tracking echocardiography has been validated for assessment
of global and regional left ventricular myocardial function which is affected in patients with obstructive CAD. The study aims the
early detection of obstructive coronary artery disease using peak systolic global longitudinal strain derived by 2D speckle tracking
in patients with chronic stable angina.
Method:
75 patients with chronic stable angina were enrolled in this cross sectional study, (Mean age was 56.69±6.96 y, 35 were
males), 42.7 % were diabetic and all patients were assessed by thorough history taking, clinical examination, 12 lead surface ECG,
conventional, speckle echocardiography and coronary angiography in Mansoura specialized medical hospital over a period of 7
months from march 2017 to October 2017.
Result:
Statistically significant decrease was found in GLPS-Avg (Global Longitudinal Systolic Peak Strain) values in patients
with obstructive CAD when compared to patients with normal coronary angiography (p<0001) and in patients with 3 or more risk
factors when compared to patients with one or two risk factors (p=0.014) and when syntax score was increasing among patients with
obstructive CAD a significant decrease in median GLPS-Avg values was noted (p<0.001), but when regional systolic strain values
were compared to affected coronary arteries no significant difference was found (p=0.844) i.e. almost identical correlation between
affected segments by speckle tracking and obstructed arteries by coronary angiography. Multivariate logistic regression analysis
showed that GLPS-Avg was found as a predictor for obstructive coronary artery disease in patients with chronic stable angina
(p=0.028 with odds ratio 31.4 and 95% CI (1.85-535)). ROC curves were established and cutoff value was determined for GLPS-Avg
as -16 with 89.8% sensitivity and 100% specificity.
Conclusion:
longitudinal strain derived by speckle tracking can be used as non-invasive simple test for evaluation of patients with
chronic stable angina and as a predictor for presence or absence of obstructive CAD.
m_areed_2040@yahoo.comCurr Res Cardiol 2018, Volume 5
DOI: 10.4172/2368-0512-C1-003