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Volume 5
Journal of Current Research: Cardiology
Heart Congress 2018
November 21-22, 2018
2
nd
Global Heart Congress
November 21-22, 2018 Osaka, Japan
Brugada syndrome and its relation to mitochondrial cardiomyopathies
Mehrnaz Ajorloo
1
and Saeed Soroush
2
1
Shahid Beheshti University of Medical Sciences and Health Services, Iran
2
Guilan University of Medical Sciences, Iran
C
ardiomyopathy is a progressive myocardial disease or heart muscle. In most cases, the heart muscle weakens and the ability to
pump blood to other parts of the body decreases. Cardiomyopathy can lead to irregular heartbeat, heart failure, disorders and
diseases of the heart valves or other complications. Some effective measures are there to resolve this problem. Cardio myopathy has
many causes that the most common one is the heart muscle is stretched and due to this stretching, the blood pumping become very
weak. In the meantime, some nucleotide changes in molecular level at the mitochondrial are led to Brugada syndrome that one of the
genetic reasons for sudden cardiac deaths is as a result of ventricular fibrillation. At the molecular level mutations that occur in the
SCN5A gene that it is encoding the alpha subunit of the sodium channels of the heart cells, they lead to this syndrome. Any disorder
that occurs in the mitochondrial respiratory chain leads to a defect in the function of the target tissue. As you know, the heart is one of
the organs that needs a lot of energy to function and energy deficiency in cells affects ion channels including this complication cause
heart disorders. Cytochrome C is part of the mitochondrial transduction of electrons and respiratory chain that it reconstructs H
2
O
and the nucleotide defects that occur in this mutation, it encompasses a wide range of diseases including myopathic disturbances to
severe multi-systemic diseases. In accordance with the provided explanations, there is a direct correlation between the disturbances
of the sodium channel that they play an important role in action potential of cardiac cell and this syndrome and created mutations
cause to decrease the function of sodium channels in the heart muscle and it prevents the precise function of the blood supply system,
because the heart is heavily dependent on the oxidative energy produced by the mother's inherited mitochondria.
Saeed.Sorush55@yahoo.comCurr Res Cardiol 2018, Volume 5
DOI: 10.4172/2368-0512-C1-003