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Page 28
Volume 5
Journal of Current Research: Cardiology
Heart Congress 2018
November 21-22, 2018
2
nd
Global Heart Congress
November 21-22, 2018 Osaka, Japan
Anti-arrhythmic and anti-inflammatory effect of low-level electrical stimulation of aortic root ventricular
ganglionated plexi in dogs with heart failure
Hong-Tao Wang
Xi’an Jiaotong University, China
Background & Aim:
Heart Failure (HF) and arrhythmia often coexist and share the similar underlying pathogenesis, including
autonomic imbalance, electrical remodeling and inflammatory reactions. Low Level-Electrical Stimulation (LL-ES) rebalances the
tone of the autonomic nervous system and has an anti-arrhythmic effect. However, it is unknown whether LL-ES can decrease
the inflammatory response and benefit patients suffering from both HF and arrhythmia. This study aimed to investigate the anti-
arrhythmic and anti-inflammatory effects of LL-ES of Aortic Root Ventricular Ganglionated Plexi (ARVGP).
Method:
20 dogs were divided randomly into drug administration (control) and LL-ES groups after performing rapid right ventricle
pacing to establish the HF model. The inducing rate of arrhythmia was measured after a programmed electrical procedure at the
baseline and drug administration or LL-ES. The bioactive factors of HF, including angiotensin II, TGF-β
,
Mitogen-Activated Protein
Kinase (MAPK) and Matrix Metallo Proteinase (MMP), were assessed. Furthermore, ventricular size and left ventricular ejection
fraction were determined.
Result:
Compared with the control group, the inducing rate of arrhythmia decreased from 40% to 10% after 4 h of LL-ES (P<0.05).
The expression of angiotensin II, TGF-β, MAPK, and MMP was down regulated significantly in the LL-ES group (P<0.05).
Moreover, the volume of the left ventricle and the ejection fraction of the left ventricle in the LL-ES group changed little (P>0.05).
Conclusion:
Short-term LL-ES of ARVGP presented both anti-arrhythmic and anti-inflammatory effects and contributed to the
treatment of HF and the associated arrhythmia.
wht506@126.comCurr Res Cardiol 2018, Volume 5
DOI: 10.4172/2368-0512-C1-003