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Volume 3
Journal of Neurology and Clinical Neuroscience
Neurology 2019 | Neuropsychology 2019 | Drug Delivery Summit 2019
June 24-25, 2019
June 24-25, 2019 | Rome, Italy
Neurology and Healthcare
3
rd
WorldDrug Delivery and Formulations Summit
Clinical and Experimental Neuropsychology
4
th
International Conference on
International Conference on
&
Executive dysfunctions associated with frontostriatal circuity in bipolar affective disorder I: Are they
associated with depression, mania or both?
Paulina Golińska
1
, Krystyna Buszman
2
, Michał Harciarek
1
1
University of Gdańsk
2
University of Silesia in Katowice
Objective:
Bipolar Affective Disorder I (BDI) has been associated with frontostriatal abnormalities and thus, executive
problems. However, it remains unclear whether executive dysfunctions in BDI are predominantly associated with mania,
depression or are state-independent. Further, executive processes are relatively heterogeneous, with different frontostriatal
circuits subserving different executive function. Specifically, whereas the Dorsolateral Prefrontal Cortex (DLPFC) has
been shown to be associated with organizational strategies, working memory and problem solving, Anterior Cingulate
Cortex (ACC) is involved in response initiation and monitoring. In addition, Orbitofrontal Cortex (OFC) seems to be to
be related with impulse control. Hence, the aim of this study was to better characterize executive problems in BDI as
well as to test if the hypothetical specificity of executive impairment in this population may indicate a dysfunction of the
specific frontostriatal circuit(s).
Participants and Methods:
Twenty-two patients with BDI (11 mania and 11 depressed) participated in this
study. DLPFC functions were assessed using: Verbal Fluency (response generation with clustering and switching
components), Digit Span, Trail-Making Test; ACC: The Verbal Fluency Test (response initiation), Stroop test; OFC:
multiple loops and altering sequence task.
Results:
Manic state was particularly associated with executive problems indicating ACC pathology. Additionally,
although both patients’ groups had deficits suggesting executive dysfunction of the circuit involving dorsolateral
prefrontal, these problems were more pronounced in patients with mania.
Conclusions:
In BDI, executive problems are particularly characteristic for patients with mania. The results of this
study will be discussed in the context of three frontostriatal circuits subserving different executive processes
Biography
Paulina Golińska is a PhD candidate in psychology at University of Gdańsk in Poland. Her interests are focused on experimental and
clinical neuropsychology. For PhD thesis, she conducting a research concerning symptoms charateristic for damages in frontal areas
in people with Parkinson’s disease (apathy, anterior-attentional system and anosognosia). She also worked as a therapist with people
after traumatic brain injuries.
golinska.paula@gmail.comJ Neurol Clin Neurosci, Volume 3