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Volume 3
Journal of Neurology and Clinical Neuroscience
Neurology 2019 | Neuropsychology 2019 | Drug Delivery Summit 2019
June 24-25, 2019
June 24-25, 2019 | Rome, Italy
Neurology and Healthcare
3
rd
WorldDrug Delivery and Formulations Summit
Clinical and Experimental Neuropsychology
4
th
International Conference on
International Conference on
&
Changes in the cognitive function of patients with early onset Parkinson´s disease
José Benjamín Herrera Aranda, Hermelinda Salgado Ceballos
and
Ana Natalia Seubert Ravelo
Universidad Nacional, México
Statement of the Problem:
Parkinson´s Disease (PD) is a movement disorder also characterized by non-motor symptoms,
that including cognitive impairment. In the Early Onset Parkinson´s Disease (EOPD) motor symptoms begins between
the 21 and 50 years old. Deep Brain Stimulation (DBS) has been used as a treatment of motor symptoms in PD, but there
is still controversy about its effects on the non-motor symptoms. Few studies have described Mild Cognitive Impairment
(MCI) and dementia in EOPD, and only other few have described effects of DBS on the cognition in these patients.
Methodology:
The present study describes the progression of MCI and dementia in 16 patients with EOPD (8 patients
with DBS and 8 with only pharmacological treatment) that were assessing between 1-7 years after initial evaluation
for inclusion in the present protocol. All patients were evaluated neuropsychologically in the follow cognitive domains
attention and working memory, memory, language executive functions, and visuoespatial abilities. The MCI and dementia
were determined according to the Movement disorder Society criteria. Descriptive statics and Fisher´s exact test was used
for the statistical analysis.
Findings:
About 25% of patients changed their status from normal cognition to MCI, of which 75% was in treatment with
DBS. About 75% of these cases changed their cognitive status in the first 3 months. However, not statistically significant
differences (p=.562) were found between patients with and without DBS by using Fisher´s exact test and no one changed
their cognitive status to dementia during follow.
Conclusion & Significance:
Apparently, progression to MCI is infrequent in EOPD, and dementia was not found, even
in patients with more than ten years after starting the first motor symptoms. According to these results, DBS could not be
a risk factor for change cognitive status from normal cognition to MCI or dementia in patients with EOPD.
J Neurol Clin Neurosci, Volume 3