4 / 7
Page 18
Volume 3
Journal of Neurology and Clinical Neuroscience
Neurology 2019 | Neuropsychology 2019 | Drug Delivery Summit 2019
June 24-25, 2019
June 24-25, 2019 | Rome, Italy
Neurology and Healthcare
3
rd
WorldDrug Delivery and Formulations Summit
Clinical and Experimental Neuropsychology
4
th
International Conference on
International Conference on
&
Hepatoprotective study of delphinium zelil
Bushra Sadaf
Leads College of Pharmacy, Pakistan
T
raditionally in India,China and Japan herbal medicine are use for liver disease treatment.A common pathological
mechanism that cause initiation and progression of hepatic damage is Oxidative stress. Traditionally
Delphinium zelil
was use for liver inflammation,diuretic and anodyne.Present study was to assess the phytochemical and hepatoprotective
activity of ethanolic and n-hexane extracts of whole dried plant of
Delphinium zelil
against paracetamol intoxicated albino
rats. The phytochemical investigation was carried on the both extracts of
Delphinium zelil
. Results revealed the presence
of following active constituents such as alkaloids, tannins, phenols, glycosides, steroids and flavonoids in n-hexane extract
and absence of tannins in ethanolic extract. Two hepatoprotective studies were performed using paracetamol intoxicated
method. In study A animals were pretreated for 7 days with ethanolic and n- hexane extracts at doses of 200 mg/kg and
400 mg/kg daily by oral rout. On 8
th
day hepatoxicity was induced by administering a single oral dose of paracetamol
(1g/kg).In study Bhepatoprotective activity of ethanolic extract at doses of 200 mg/kg and 400 mg/kg was assessed by
concurrent administeration of sub-acute dose of paracetamol (500 mg/kg) daily dose by oral rout. Results showed that
there was significant decrease in biochemical parameters (AST, ALT, ALP and bilirubin) values of
Delphinium zelil
ethanolic and n-hexane extracts 200 mg/kg and 400mg/kg dose treated rats when compared with paracetamol intoxicated
rats serum biomarkers Histopathological findings on toxic models showed necrosis, fibrosis, inflammation with sinusoidal
and portal vein congestion and central vein dilation.Both extracts of
Delphinium zelil
ethanolic and n-hexane 200 mg/kg
and 400 mg/kg doses treated rats histopathological results revealed these altered parameters towards normal values,which
were compared with silymarin.This study suuports the use of active phytochemical constitutents from
Delphinium zelil
ethanolic and n-hexane extracts against in liver diseases. Thes phtochemicals may be developed as drugs for the treatment
of liver diseases.
Biography
Bushra sadaf is a Pharmacologist. Currently teaching Physiology and Pharmacology in Leads college of Pharmacy. She has experience
as clinical and Hospital pharmacist in shaukat khanaum memorial cancer hospital and research centre and in Cardiac Hospital. Free
radical is major cause of many major disease in human. In Pakistan out of 10 one is a hepatic patient. She follows ancient uses of herbs
and then she adopts lab tests and phytochemical analysis reveal antioxidant activity of above stated plant extract. Histopathological
and Biochemical parameters revealed Hepatoprotective activity of Delphinium zelil and soon dosage form available as futher research
performed on it.
dr.bushra22@yahoo.comJ Neurol Clin Neurosci, Volume 3