4 / 15
Page 35
Volume 3
Journal of Neurology and Clinical Neuroscience
Neurosurgery 2019 & Neuroimmunology 2019
May 22-23, 2019
Neurosurgery and Neurological Surgeons
Neuroscience and Neuroimmunology
May 22-23, 2019 London, UK
6
th
Annual Meeting on
9
th
Global Summit on
&
J Neurol Clin Neurosci, Volume 3
Intensity-dependent immune-modulatory effects of exercise training in experimental
multiple sclerosis
Ofira Einstein
Ariel University, Israel
Background: Exercise training (ET) has beneficial effects on multiple sclerosis (MS) and its animal model experimental
autoimmune encephalomyelitis (EAE). However, the intensity-dependent effects of ET on the systemic immune system in EAE
remain undefined.
Objective: (1) To compare the systemic immune-modulatory effects of moderate vs. high intensity ET protocols in EAE; (2) To
investigate whether ET affects autoimmunity selectively, or causes general immunosuppression.
Methods: Healthy mice were subjected to moderate or high intensity treadmill running programs. Proteolipid protein (PLP) -induced
transfer EAE was utilized to examine ET effects specifically on the systemic immune system. To examine effects of ET on systemic
autoimmunity, lymph-node (LN)-T cells from trained- vs. sedentary donor mice were transferred to naïve recipients and EAE severity
was assessed. LN-T cells derived from donor trained vs. sedentary PLP-immunized mice were analyzed in vitro for proliferation assays
and cytokine and chemokine receptor genes expression. T cell-dependent immune responses of trained- vs. sedentary mice to the non-
autoantigen ovalbumin and susceptibility to Escherichia coli - induced acute peritonitis were examined.
Results: High intensity training in donor mice induced stronger inhibitory effect than moderate intensity training on disease
development and PLP-reactivity of LN- T cells derived from PLP- immunized mice. High intensity training also inhibited LN- T
cell proliferation in response to ovalbumin immunization. E-coli bacteria counts and dissemination were similar in trained and
sedentary mice. Conclusion: High intensity training possesses superior modulatory effects on autoimmunity in EAE, while also
inhibiting T cell responses to ovalbumin, but sustains immune defenses against E-coli bacteria.
Biography
Prof. Einstein's area of specialization is neuro-immunology and neuro-regeneration in neurodegenerative diseases, specifically on
animal models of human Multiple Sclerosis (MS). Her major studies concern on the neurobiology of neural stem cells and cell therapy
in neurodegenerative diseases. Her work published in 2003 was the first to show that transplanted neural stem cells have anti-
inflammatory effects on the rodent brain. This finding was a breakthrough for further research of her group, as well as other research
groups around the world. Her current research focuses mainly on neuro-immunological, neuro-protective and neuro-regenerative
effects of exercise training on neurodegenerative diseases, particularly on experimental autoimmune encephalomyelitis (EAE) the
animal model of MS. The studies involve animal training, clinical evaluations, histopathological analyses, cell cultures and molecular
biology techniques.
ofirae@ariel.ac.il