pediatrics-congress-2019-posters-abstracts

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Volume 03

Stem Cells 2019 & Pediatrics Congress 2019

November 06-07, 2019

Journal of Child and Adolescent Psychiatry

November 06-07, 2019 | Tokyo, Japan

STEM CELLS AND REGENERATIVE MEDICINE

PEDIATRICS AND CHILD CARE

International Conference on

World Congress on

J Child Adolesc Psych, Volume 03

Peculiarities of the course of Juvenile Arthritis depending on the polymorphism of

Proinflammatory Cytokine genes

Artsymovych A

Shupyk National Medical Academy of Postgraduate Education, Ukraine

Introduction

: The change in the nature of treatment led to a significant change in the course of juvenile idiopathic arthritis (JIA).

Among the DMARDs, the antifolate drug methotrexate (MTX) retains its positions. The main therapeutic targets for biological

therapy are pro-inflammatory cytokines (interleukin 1, 6 (IL-6), tumor necrosis factor α (TNF-α)). The dependence of the course

and possibilities of JIA therapy on genetic features has not been studied enough.

Conclusion

: The study of the genes IL6(G-174C), TNFα(G308A) and MTHFR may suggests some features of the course of the

disease, which may allow optimizing and individualizing its treatment.