pediatrics-neonatal-healthcare-2017-scientifictracks

13 / 20

Page 27
Pediatrics & Neonatal Healthcare 2017
September 11-12, 2017 Los Angeles, CA, USA
14th World Pediatrics &
Neonatal Healthcare Conference
Journal of Pediatric Health Care and Medicine Volume 1, Issue 1
Notes:
Prevalence of hypothyroidism in pediatric thalassemia in Dr. Soetomo Hospital Surabaya
Nur Rochmah, Indah Ratna Sari, Laili Mufidah, Irwina Rahma Andriani, Andi Cahyadi, Maria C Shanty Larasati, Mia Ratwita
Andarsini, Muhammad Faizi, IDG Ugrasena and Bambang Permono
Airlangga University, Indonesia
Background: Hypothyroidism is the common endocrine complications in thalassemia patients, caused by iron
overload and iron depotition in thyroid gland. Early recognition and prevention may improve the quality of
life. Thyroid dysfunction usually occured after 10 year in transfusion dependent thalassemia, unfortunately
hypothyroidism is not clinically observed.
Objective: To determine the prevalence of hypothyroidsm pediatric thalassemia patients in Dr. Soetomo Hospital
Surabaya
Methods: This cross sectional study evaluated children aged 3-18 years old with thalassemia at hematology-
oncology outpatient clinic, Dr. Soetomo Hospital from February to March 2017. Inclusion criterias were: patients
had regular transfusions more than one year. Clinical manifestations and biochemical analysis were taken.
Subclinical hypothyroidism was defined as normal FT4 with high TSH; central hypothyroid: low FT4 and low to
normal TSH; overt primary hypothyroidism: low FT4 and high TSH. Patients with hypothyroidsm were divided
into 2 group, group 1(<11yo), and group 2(≥11yo).
Result: 106 patients were included in the study. 56 were male, mean age was 10.66 years. Moderate malnutrition
was obsereved in 29.3%; mean of ferritin level was 3703.82±335.69; mean of age of start transfusion was 6.16.
Mean of pre-transfusion hemoglobin level was 5.14±1.2. Impaired thyroid function were observed in 27 (25.2%)
out of 106 patients: 12 (12.1%) patients subclinical hypothyroidism; 13 (13.1%) patients central hypothyroid,
and 2 (2.0%) patients overt primary hypothyroidism. Comparison between group 1 and group 2 was significant
(p<0.001).
Conclusion: Hypothyroidism is more prevalent in aged 11 year old and more. Thyroid function should be
followed periodically.
Biography
Nur Rochmah is working as a Lecturer of Department of Pediatrics, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital. Surabaya. East Java.
Indonesia.