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International Journal of HIV and AIDS research

Page 9

http://parasitology.cmesociety.com

|

http://std.cmesociety.com

Notes:

International Conference on

September 21-22, 2017 San Antonio, TX, USA

&

Sexually Transmitted Diseases, AIDS and Parasitic Infections

Parasitology, Infectious Diseases, STDs and STIs

Tesfaye Belay

Bluefield State College, USA

Cold-induced stress and

chlamydia

genital infection on a mouse model

G

enital infection by

Chlamydia trachomatis

(CT) is the most common bacterial sexually transmitted disease

worldwide. The infection can cause serious reproductive health complications including pelvic inflammatory

disease and infertility. Stress is considered as a risk factor for various infections, however, its effect on chlamydia

genital infection remains unknown. In this study, exposure of mice to cold water for five minutes every day for 24

days resulted in a greater intensity of

Chlamydia muridarum

genital infection and a high rate of infertility. Cold-

induced stress was associated with decreased mRNA and protein levels of major cytokines and chemokines in the

spleen and genital tract but with increased noradrenaline (NE) and adrenaline levels. Furthermore, supplement

of NE

in vitro

exerted an immunosuppressive effect on splenic T-cell production of cytokines, but a decreased

C.

muridarum

shedding in the genital tract of β1Adr/β2Adr receptor knockout mice. These results suggest that cold-

induced stress induces the production of catecholamines, which may play a critical role in the modulation of the

immune system leading to increased susceptibility and greater intensity of

Chlamydia

genital infection that could

promote the development of complications including

Chlamydia

-induced infertility in mice.

Biography

Dr. Tesfaye Belay is currently a professor of biology at Bluefield State College (BSC), WV. He earned a Bachelor of Science in biology from Addis Ababa Uni-

versity in Ethiopia and Masters of Science in microbiology and PhD in botany and plant pathology from Michigan State University. Before joining BSC in 2005,

he served as postdoc at Georgia State University, Morehouse School of Medicine, Clark University and an adjunct instructor of biology at Morehouse College

and Spelman

College.He

has authored and co-authored 27 articles that have appeared in many peer-reviewed scientific journals. He has trained more than 50

undergraduate students in basic biomedical research that have presented their research findings at both local and national meetings. He has won several awards

including outstanding researcher award from all Thurgood Marshall Member institutions throughout the nation 2009, faculty of the year at BSC in 2015. Dr. Belay

is a member of the American Society for Gravitational and Space Research, American Society for Microbiology, and the Association of American Immunologists.

tbelay@bluefieldstate.edu