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http://parasitology.cmesociety.com|
http://std.cmesociety.comInternational Journal of HIV and AIDS research
International Conference on
&
Sexually Transmitted Diseases, AIDS and Parasitic Infections
Parasitology, Infectious Diseases, STDs and STIs
September 21-22, 2017 San Antonio, TX, USA
New directions for Leishmania therapy; How about electromagnetic radiation
Marjorie A Jones
1
, Benjamin D Dorsey
1
, David L Cedeño
2
and
Ricardo Vallejo
2
1
Illinois State University, USA
2
Millennium Pain Center, Bloomington, USA
S
ince
Leishmania
diseases are becoming more wide spread and there are few good drug therapies, new
directions of treatments should be explored. With this in mind, we engaged in evaluating the effects of Pulsed
Radio Frequency (PRF) on L. tarentolae, as a model system (Taylor et al. 2010) for cell viability, ability to secrete
acid phosphatase, as well as motility (as evaluated by microscopy). Vannier-Santos et al. (1995) had reported that
Leishmania secreted acid phosphatase (SAP) which has an important role in the infectivity by Leishmania. We
were especially interested in the potential effect of electric fields on
Leishmania tarentolae
in culture and some
clinical implications due to the induced release of secreted acid phosphatase from
Leishmania
. Our data have
implications for clinical treatments of cutaneous Leishmania infections.
majone3@ilstu.edu