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Volume 3

Journal of Reproductive Biology and Endocrinology

WCGO2019

May 13-14 , 2019

Gynecology and Obstetrics

May 13-14 , 2019 Tokyo, Japan

2

nd

World Congress on

Notes:

Evaluation of the effect of trans-vaginal ovarian needle puncture on women with

polycystic ovary syndrome

Mohamed Mouselhy Farrag

Suez Canal University, Egypt

Introduction:

Polycystic Ovary Syndrome (PCOS) is a syndrome of ovarian dysfunction showing cardinal

features of hyper-androgenism and polycystic ovarian morphology. Many therapeutic strategies have been

used to restore ovulation in women with PCOS who are infertile. Ultrasound-guided transvaginal ovarian

needle puncture is a new surgical method used to induce ovulation.

Methods:

This prospective interventional study was conducted in a tertiary care hospital and was performed

on 54 women with clomiphene resistant PCOS with primary or secondary infertility divided into two groups.

Group I Included twenty-seven patients who received aromatase inhibitors (letrozole 2.5mg) twice daily

starting from the 2nd day of menstrual cycle for 5 days, and Follicle Stimulating Hormone (FSH) administered

with 75 IU daily from cycle day 3 and maintained for up to the 14th day of the cycle. Group II Included twenty-

seven patients who underwent utrasound- guided transvaginal needle ovarian puncture prior to the induction

of ovulation by the same protocol used in group I from the next cycle for 3 months. For all patients, serum

FSH, LH, and free Testosterone levels were measured on day 3 of the next menses. All patients were monitored

in the early and late parts of the follicular phase. The ultrasound data taken from the day 7 of the menstrual

cycle was collected and monitored to determine the ovarian response and follicular growth. All patients were

monitored for the mean follicular diameter, number of dominant follicles and endometrial thickness on day

of hcG administration

Results:

The ovulation rate with trans-vaginal ovarian puncture in group II was (84%) which is higher than

that in group I (62.5%) with a statistically significant difference. Also, the cumulative pregnancy rate in group

II was higher (33.3 %) compared to15 % in group I. There is a marked decline in LH level in group II which

was treated by trans-vaginal ovarian puncture that of group I, and this was reflected on LH/FSH ratio which

markedly declined in the group II. Free testosterone showed significant decline in group II.

Conclusion:

Ultrasound guided trans-vaginal ovarian needle puncture is an effective method for improving

the outcome in women with PCOS who are resistant to clomiphene citrate. It resulted in a significant change

in baseline hormonal profile level of LH and serum testosterone.

mouselhy@hotmail.com

J Reprod Biol Endocrinol, Volume 3