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Notes:
Volume 3
Journal of Reproductive Biology and Endocrinology
WCGO2019
May 13-14 , 2019
Gynecology and Obstetrics
May 13-14 , 2019 Tokyo, Japan
2
nd
World Congress on
Can metformin limit weight gain in the obese with pregnancy?
Eman Aly Abd El Fattah
Alexandria Faculty of Medicine, Egypt
Background:
Maternal overweight and obesity is associated with many obstetric complications. Obesity
is linked to insulin resistance. Improving insulin sensitivity may therefore account for weight reduction.
Metformin was found to be effective in type 2 diabetes and polycystic ovarian syndrome through improving
insulin sensitivity. Several studies proved its efficacy in the obese non- pregnant, but its role during pregnancy
is not yet well-established. In this study, we are testing the ability of metformin to limit weight gain with
pregnancy and therefore reducing complications as gestational Diabetes and hypertension.
Methods:
A prospective study was conducted in Alexandria, Egypt. The study was registered in the South
African Cochrane Centre under an identification number PACTR201505001142202. Two Hundred
participants with a BMI of ≥35 Kg/m2, pregnant in the early second trimester, were equally divided into two
groups; in which group 1 will receive metformin 500 mg twice a day and group 2 will receive placebo. Prior to
inclusion, 75 g oral glucose tolerance test, fasting insulin, fasting blood glucose, 1 h and 2 h glucose blood and
HbA1C were measured. Both groups were followed up monthly for weight and for pregnancy complications
namely gestational diabetes and pre-eclampsia till 36 weeks of pregnancy.
Results:
There was a significant difference in the weight gain and the one-hour blood sugar measurement
between the two groups, but not in the occurrence of pregnancy complications namely gestational diabetes
and hypertension.
Conclusions:
Metformin succeeded to limit weight gain the obese with pregnancy.
Biography
Dr. Eman Abd Elfattah is a assistant professor of obstetrics and gynecology Alexandria faculty of medicine ,EGYPT since 2015.
Lecturer of obstetrics and gynecology at the same faculty since 2012. Doctorate degree in high risk pregnancy and infertility 2012.
Researcher in infertility and high-risk pregnancy since 2007. Researcher in feto-maternal medicine since2002. Master’s degree in
obstetrics and gynecology 2000. Residant at El-shatby maternity university hospital from 1996 to 2000. Mbbch of medicine 1995.
eman0eman0eman7@gmail.com