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Page 22
Volume 1
Journal of Blood Disorders and Treatment
World Hematology 2018
October 22-23, 2018
October 22-23, 2018 Warsaw, Poland
10
th
World
Hematology and Oncology Congress
Glucose-6-phosphate dehydrogenase deficiency in jaundiced neonates and its relationship with severity of
hyperbilirubinemia
Nazish Mazari
1
, Umme Habiba
2
and Naseem Akhter
3
1
University of Health Science, Pakistan
2
University of Lahore, Pakistan
3
Multan Medical & Dental College, Pakistan
Statement of the Problem:
G6PD is a house keeping enzyme produced NADPH reduces free radicals and protects the body. Almost
7.5% of world population is carrier of G6PD deficiency. Neonatal jaundice is one of the manifestations of G6PD deficiency, observed
in one third of newborns. Severe hyperbilirubinemia can cause kernicterus and even death. The purpose of this study is to determine
the frequency of Glucose-6-Phosphate dehydrogenase deficiency in neonates with hyperbilirubinemia. Find the association between
level of G6PD deficiency and severity of hyperbilirubinemia.
Method:
We included 100 neonates with jaundice after excluding the other risk factors for hyperbilirubinemia. Initially screening
for G6PD deficiency done with qualitative methods and deficient neonates were confirmed with quantitative method. History,
examination and investigations like routine hematological investigations and total and direct bilirubin, Coombs test, G6PD qualitative
and quantitative assay were done in all subjects.
Findings:
In this study following finding were found 6% were G6PD deficient, in majority jaundice appeared on day third, maternal
age was found to higher in deficient neonates. There is increased rate of complication and death was found in deficient group,
bilirubin was higher and platelets were lower in deficient group that was statistically significant.
Conclusion:
G6PD deficiency is an important cause of neonatal jaundice and severe hyperbilirubinemia in newborns. Hemolysis
may not be the sole factor for the development of jaundice in G6PD deficient neonates. There is association between lower enzyme
activity and hyperbilirubinemia. Early identification and treatment may reduce the mortality and morbidity.
Biography
Nazish Mazari is an Assistant Professor in the Department of Hematology at University of Health Sciences Lahore, Punjab, Pakistan.
nazishmazari@gmail.comNazish Mazari et al., J Blood Disord Treat 2018, Volume 1