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Page 24
Volume 1
Journal of Blood Disorders and Treatment
World Hematology 2018
October 22-23, 2018
October 22-23, 2018 Warsaw, Poland
10
th
World
Hematology and Oncology Congress
Parvovirus B19 in patients of acute lymphoblastic leukemia with prolonged cytopenia
Omer Naseem, Ayishah Chaudhary, Nadia Sajid, Shahjahan and Shahida Mohsin
University of Health Sciences, Pakistan
Introduction:
Parvovirus B19 is a small DNA virus and an important cause of cytopenia(s) and suppressed erythropoiesis. It is known
to replicate exclusively in erythroid progenitor cells and also known to cause suppression of megakaryocytic colonies. Persistent B19
infection tends to occur in hematological malignancies. The aim of the study was to find the frequency of parvovirus b19 infection in
patients with Acute Lymphoblastic Leukemia (ALL) with prolonged cytopenia.
Method:
49 patients suffering from ALL were enrolled for the study. All patients had persistent prolonged cytopenia for greater than
10 days beyond the scheduled date of next chemotherapy. B19 infection was investigated by detection of viral DNA in serum by Real
time PCR.
Result:
Among the 49 patients enrolled with ALL only 6 (12.2%) were found to be Parvovirus B19 DNA positive. The infection was
not suspected on clinical grounds on any of the patients. Most of the patients were males (40 male and 9 females). All the patients
were cytopenic with anemia, thrombocytopenia or neutropenia.
Conclusion:
We concluded that patients with ALL are at particular risk of persistent B19 infection. Moreover, it is important to
consider B19 infection as a possible cause of unexplained cytopenia(s) in these patients. Thus, screening for parvovirus B19 DNA
by quantitative polymerase chain reaction in cytopenic patients with ALL is suggested. Moreover, it is important to consider B19
infection as a possible cause of unexplained cytopenia(s) in these patients. Thus, screening for parvovirus B19 DNA by quantitative
polymerase chain reaction in cytopenic patients with ALL is suggested.
Biography
Omer Naseem from FMH College of Medicine and Dentistry has completed his House job from Jinnah Hospital, Lahore, Pakistan. He has worked with GIZ; an NGO of
international repute on safe blood transfusion project where he was involved in inspections of blood bank practices and working to enhance the safety measures involved
in blood banking in Pakistan. He is currently pursuing his MPhil in Hematology at University of Health Sciences Lahore, Pakistan.
omer_naseem740@hotmail.comOmer Naseem et al., J Blood Disord Treat 2018, Volume 1