world-hematology-nursing-care-2019-posters-abstracts

Page 43

Volume 2

July 24-25, 2019 | Rome, Italy

World Hematology 2019 & Nursing Care 2019

July 24-25, 2019

Journal of Blood Disorders and Treatment

WORLD CONGRESS ON NURSING CARE

WORLD HEMATOLOGY AND ONCOLOGY CONGRESS

Gastrointestinal stromal tumor presenting as lung mass: A case report

Kristine Anne B Monte

Cardinal Santos Medical Center, Philippines

astrointestinal stromal tumors (GISTs) are rare neoplasms of the

gastrointestinal tract commonly seen in middle-aged and elderly

adults with the most common location in the stomach and small intestine.

These tumors most frequently metastasize to the liver and peritoneum and

it is relatively rare that the tumor invades the lung and the bones. GISTs

outside the gastrointestinal tract appear to relapse more frequently. The

treatment of unresectable GISTs is systemic treatment with tyrosine kinase

inhibitors. We present a case of a 20-year-old Filipino male with a 2-week

history of exertional dyspnea which on work up showed a left pulmonary

mass consistent with a high grade gastrointestinal stromal tumor with no

evidence of intra-abdominal GIST on work-up. Immunohistochemistry

revealed spindle cells positive for CD 117, DOG-1, and CD 56, negative

for CK, TTF-1, SMA, desmin, S-100, and CD34. He underwent attempted

video-assisted thoracoscopic surgery (VATS), open thoracotomy, lung

mass biopsy, tumor debulking and decortication and began treatment with oral imatinib mesylate (Gleevec) at a dose of 400mg/

day but was refractory after 3 months of treatment. The patient had pulmonary infection and evidence of tumor progression at

that time. He then underwent radiotherapy and a second line pazopanib 400mg/day was started. Partial response was achieved

after two to three months. The patient is currently stable and with good functional capacity.

Figure. (A,B) The lung mass was composed of spindle cells and epithelioid

cells, (C,D) positive CD 117, strong and diffuse, (E,F) positive DOG-1,

(G,H) positive CD 56, (I) negative CD 34

J Blood Disord Treat, Volume 2