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Volume 3
Current Research: Integrative Medicine
Chronic Diseases 2018
July 16-17, 2018
Chronic Diseases
July 16-17, 2018 Berlin, Germany
2
nd
International Conference on
Curr Res Integr Med 2018, Volume 3
DOI: 10.4172/2529-797X-C1-003
Complication of MRC UKALLX protocol in pediatric acute lymphoblastic leukemia: Aretrospective analysis
Ehsan Shahverdi
1,
2
, Mohammad Ali Ehsani
3
, Farzaneh Tavakoli
4
, Mohammadreza Mohamadimaram
4
, Fatemeh Feizi
4
, Peyman Salamati
3
and Alireza Lotfipour
3
1
High Institute for Research and Education in Transfusion Medicine, Iran
2
MAHAK Pediatric Cancer Treatment and Research Center, Iran
3
Tehran University of Medical Sciences, Iran
4
Shahid Beheshti University of Medical Sciences, Iran
Background & Aim:
Leukemia has the highest incidence in pediatric malignancy and ALL is the most common. In the recent years,
treatment has been remarkably improved and now most of the patients are cured successfully. UKALL-X is a protocol with 1 or 2
consolidation therapy phase regarding to the patient’s conditions. The aim of this study was to investigate the response to therapeutic
procedure and complications related to consolidation therapy phase in this protocol.
Material & Methods:
In this retrospective cross sectional study, ALL patients from 2008 to 2015 in Bahrami Pediatric Hospital, Iran
were enrolled. Patients’ demographic information and clinical characteristics, including age, gender, ALL morphology subtype, WBC
and neutrophil counts, Hb level, length of hospitalization and outcome were collected.
Results:
67 ALL patients who were under UKALL-X protocol were enrolled for analyzing. 28 (41.7%) and 19 (28.3%) cases were
between 0-5 and 10-15 years old, respectively. 44 patients )65.6%) were boys and 23 cases (34.4%) were girls. 7 patients (10.7%)
relapsed in the 3 years of diagnosis. 50 subjects (74.6%) had an overall survival of 3 years. 47% of mortalities occurred in 0-5 years old
patients. 45 (67.2%) and 17 (51.5%) of patients were L1 and L2, respectively. Among 33 cases received the first phase of consolidation,
17 patients (51.5%) had experienced neutropenia. Neutropenia happened in 19 patients among 35 cases (54.2%) who received the
second line therapy. There was no report of mortality caused by neutropenia subsequent to consolidation. There was no significant
association between age and mortality and neither age and incidence of neutropenia subsequent consolidation therapy.
Conclusion:
Considering 3 year survival, no mortality report related to consolidation-therapy-induced neutropenia and low
percentage of relapse in this study can suggest that this protocol is an appropriate treatment strategy in countries such as Iran.
shahverdi_ehsan@yahoo.com