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Volume 3
Current Research: Integrative Medicine
Chronic Diseases 2018
July 16-17, 2018
Chronic Diseases
July 16-17, 2018 Berlin, Germany
2
nd
International Conference on
Effects of nutrition on epidermolysis bullosa acquisita
Anne Braun, Christian D. Sadik
Department of Dermatology, University of Luebeck, Luebeck, Germany
Statement of the Problem:
Epidermolysis bullosa acquisita (EBA) belongs to the group of pemphigoid diseases, a family of chronic-
remitting autoimmune skin blistering diseases (ASBD). These diseases are hard to treat with no specific medication available and are
associated with an increased mortality rate. Methodology & Theoretical Orientation: In the last years, the gut microbiota has been
shown to affect the immune system systemically. Disease severity of murine models of e.g. rheumatoid arthritis and gout can be
modulated by treatment with acetate, a short chain fatty acid (SCFA) and main microbial fermentation product of dietary fibers. The
production of microbial products, modulating immunity, is determined by the composition of the gut microbiota, which is largely
effected by nutrition. Nutrition can also directly modulate the immune system, for example by polyunsaturated fatty acids (PUFA).
Plasma levels of lipid mediators, known to modulate the immune system, are metabolites of PUFAs, which are components of fish
oil. Dietary fish oil supplementation can increase serum PUFA levels. So far, the effects of nutrition and the gut microbiota on ASBDs
were unknown. We therefore tested different diets and supplements in an antibody-transfer-induced EBA mouse model. Findings:
We could show that neither a high fat nor a fish oil rich diet effect EBA disease severity. The same is true for a fiber-rich diet as
well as oral treatment with the short chain fatty acids acetate, propionate or butyrate. Also, depletion of the gut microbiota using an
antibiotic-cocktail does not affect disease severity. Conclusion & Significance: Nutrition does not seem to have a major impact on
EBA disease progression in a mouse model of EBA.
Biography
Anne Braun is currently working on her PhD thesis studying the effects of nutrition on an autoimmune disease. She obtained her Master of Science in Molecular
Lide Science at the University of Lübeck, Germany, in 2015.
anne.braun@uksh.deAnne Braun et al., Curr Res Integr Med 2018, Volume 3
DOI: 10.4172/2529-797X-C1-003