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Joint Event
November 29-30, 2019 | Frankfurt, Germany
28th International Conference on 3rd International Conference on
Diabetes and Endocrinology Diabetes and Metabolism &
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9 CONGRESS
DIABETES
2019
DIABETES
Journal of Endocrine Disorders & Surgery | Volume 3
The association between osteoporosis and microvascular complications among egyptian
type 2 diabetic patients
Hytham R Badr
Menoufia University, Egypt
Objectives: Diabetes mellitus may adversely influence the
bone quality through the regulation of bone cells. However,
several studies have demonstrated increased risk of fracture
in diabetic patients in spite of normal or even higher bone
mass density BMD. The aim of this study was to evaluate
the association between osteoporosis and micro vascular
complications among Egyptian type 2 diabetic patients.
Methods: A prospective study of 78 patients with T2DM
was enrolled. They were classified into two groups. Group
I (Micro vascular group) included 39 diabetic patients
with microvasular complications. Group II (control group)
included 39 patients without microvasular complications.
Group I was subdivided into 3 subgroups according to the
number of microvasular complications. Age, gender, duration
of diabetes, hypertension and BMI were documented.
FBS, 2hPPBG, foot examination, Fundus examination and
Albumin /creatinine ratio were calculated. Dual Energy X-ray
Absorptiometry (DEXA) and serum osteocalcin were done to
both studied groups.
Results: There was no significant difference between the two
studiedgroups in theDEXAscan results, themean least T score
of the microvasular group was -1.4 and that of the control
group was -1.2 (P value = 0.27). The mean osteocalcin level of
the micro vascular group was 35.8, while that of the control
group was 13.8 showing significant difference between the
two groups (P value = 0.03). Themean osteocalcin level of the
microvascular1 subgroupwas 17.8, that of themicrovascular2
subgroup was 23.04 and that of the microvascular3 subgroup
was 45.4 showing highly significant difference between the
three subgroups (P value < 0.001).
Conclusion: Osteoporosis diagnosed by elevated level
of serum osteocalcin is more prevalent in T2DM with
microvascular complications and its prevalence increases
with the increased number of these complications. However,
DEXA scan is not reliable in diagnosis of osteoporosis.
Speaker Biography
Hytham R. Badr is a lecturer of diabetes and endocrinology, Menoufia
University, Egypt. He has doneMD of internal medicine in 2019 andMaster
of internal medicine in. 2016.
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