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Volume 3

Journal of Pharmacology and Medicinal Chemistry

Nanomedicine 2019

Biotechnology 2019

May 20-21, 2019

May 20-21, 2019 London, UK

4

th

World Biotechnology CONGRESS

Nanomedicine and Nanotechnology

4

th

International Conference on

&

Development of versatile biological models to study nanodevices biomedical potential

Morgane Daurat

Institut des Biomolécules Max Mousseron, France

T

he development of personalized and non-invasive therapies based on new nanoparticles is a major challenge in medicine. In

this context, we studied different nanoparticles for cancer therapy.

Firstly, we analyzed the biological efficiency of hollow organosilica nanoparticles. Porous systems are used to be applied to

drug adsorption and delivery. In this case, we have loaded two anti-cancer drugs, which have been used to perform in vitro

investigations in order to demonstrate their biocompatibility and their potential as drug carrier vehicles to treat cancer.

Moreover, nanoscience has grown considerably in cancer treatment with nanoparticles activated with stimuli as Mn2+-doped

Prussian blue nanoparticles. They are many advantages as their flexible structure, porosity and biocompatibility. Indeed, Prussian

blue has been approved by the Food and Drug Administration for human. We have demonstrated for the first time that these

nanoparticles acted as efficient agents for photothermal therapy under Two-Photon Excitation (TPE) and induce an almost

eradication of malignant cells.

Finally, in order to respond to increasing demand for new therapies, the PhotoDynamic Therapy (PDT) has arisen as an alternative

to chemo- and radiotherapy for the non-invasive selective destruction of small tumors. PDT is based on photosensitizers activation

by irradiation. To enhance the selectivity towards tumor cells and the efficiency of PDT, the photosensitizers are encapsulated

in Periodic Mesoporous Organosilica (PMO) nanoparticles. To go further in the biomedical proof of concept of therapeutic

nanoparticles, we are currently developing an animal model as Danio rerio (zebrafish) to study cancer. We have implanted

fluorescent human cancer cells in zebrafish larvae in order to establish a detectable tumor xenograft. Then, we have intravenously

injected PMO for TPE-PDT in zebrafish and irradiated the tumor site with a pulsed laser. The strong decrease in tumor size let us

imagine developing such model to test the biomedical potential of different nanoparticles.

Biography

Morgane Daurat is born in 1991 in Béziers (France). She is a PhD student in third year at Institut des Biomolécules Max Mousseron in

Montpellier (France). She works on the development of biological models to study nanoparticles biomedical potential and on lysosomal

diseases for the company NanoMedSyn (Montpellier, France). She is co-author of nine articles.

morgane.daurat@etu.umontpellier.fr

J Pharmacol Med Cheml, Volume 3