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Page 35
Volume 2
Journal of Clinical Diagnosis and Treatment
Annual Nephrology & Chronic Diseases 2019
May 20-21, 2019
Nephrology
Chronic Diseases
May 20-21, 2019 London, UK
19
th
Annual Conference on
3
rd
International Conference on
&
HIV, Hepatitis B & Hepatitis C
Lia Millnaise Jones
1
, Jaswinder Rai
2
, Dr Stephven Keay
3
and
Professor Geraldine Hartshorne
1
1
Warwick Medical School, UK
2
Centre for Reproductive Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX
3
Centre for Reproductive Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry
Background:
This mixed methods study consists of a literature review
and a service evaluation of a leading fertility centre. The literature
review identifies best practice in the avoidance of the transmission
of viruses during assisted conception in patients carrying HIV and
hepatitis B/C, and how this affects their pregnancy outcomes.
Aims:
To identify best practice in avoiding transmission of viruses
during assisted conception in people with HIV and Hepatitis B (HBV)
and Hepatitis C (HCV). To evaluate current conception methods for
viral positive families at the Centre for Reproductive Medicine (CRM),
and compare them with published data to determine success and opportunities for improvement.
Methods:
An online literature search amassed 116 studies for analysis
and 10 papers were shortlisted. From these papers, data was collected
such as author, viral illness, and which parent affected. For the service
evaluation, a list of viral positive patients receiving treatment at CRM in
the past 5 years was assessed for treatment method and outcome.
Results:
The pregnancy rate for viral positive families at CRM was 43%
and the live birth rate was 30.8%. The live birth rates for HIV, HBV and HCV were 13.3%, 35.9% and 33.3%,
respectively. At p <0.05, the p-value was 0.32663, meaning there was not a statistically significant difference
between pregnancy and live birth rates where the male was seropositive vs the female.
Conclusion:
Assisted conception outcomes are worse when the female is seropositive, rather than the male,
for HIV, HBV and HCV. Options for viral positive men, such as sperm washing, are safe and effective. Viral
positive patients treated at the Centre for Reproductive Medicine have higher pregnancy and live birth rates
than their viral negative counterparts.
Key words:
Hepatitis B virus, Hepatitis C virus, HIV, intracytoplasmic sperm injection, in vitro fertilisation.
Biography
Lia Millanaise Jones is a third-year medical student at Warwick Medical School with an interest in Obstestrics and Gynaecology, and
surgical research. She graduated with a First Class Honours in Medical Science from De Montfort University in 2016.
liajones1994@live.co.ukLia Millanaise Jones et al., J Clinical Diagnosis and Treatment, Volume 2