nephrology-chronic-diseases-2019-scientifictracks

8 / 10

Page 33
Volume 2 Journal of Clinical Diagnosis and Treatment Annual Nephrology & Chronic Diseases 2019
May 20-21, 2019
Nephrology
Chronic Diseases May 20-21, 2019 London, UK
19th Annual Conference on
3rd International Conference on
&
Factors associated with right ventricular dysfunction among patients with
hypersensitivity pneumonitis
Elena Leonova
Federal Central Tuberculosis Research Institute, Russia
Statement of the Problem: Cardiovascular diseases are the most common comorbidities among patients with
chronic lung diseases (CLD). As we know, right heart failure is very severe complications of CLD, which
contributes significantly to morbidity and mortality. However, there is very little literature describing factors
associated with right ventricle (RV) dysfunction among patients with chronic hypersensitivity pneumonitis
(HP). The purpose of this study was to investigate factors associated with the RV systolic dysfunction among
patients with chronic HP.
Methodology and Theoretical Orientation: We identified 86 patients with chronic HP, who underwent
echocardiography, spirometry, plethysmography, diffusing capacity of carbon monoxide (DLCO),
bronchoscopy and lung biopsy. Pulmonary high-resolution computed tomography (HRCT) was assessed by
Kazerooni scale (ground glass and lung fibrosis). Aortic pulse wave velocity (PWV) and body mass index also
were evaluated as well. RV systolic function was assessed among all subjects using different methods (tricuspid
annular plane systolic excursion (TAPSE), RVmyocardial performance index (MPI) and RV systolic excursion
velocity by tissue Doppler (S ′).
Findings: RV systolic dysfunction was found in 40.7% of subjects by TAPSE and 38.4% by RV MPI and
S ′.All parameters of RV systolic function correlated with total lung capacity (p<0.01), DLCO, HRCT (lung
fibrosis and ground glass (p<0.001)), PWV (p<0.001). Multivariate regression analysis showed that the factors
associated with RV systolic dysfunction were lung fibrosis (p=0.001), DLCO (p=0.003) and PWV (p=0.008).
Conclusion and Significance: Systolic function of the right ventricle is associated with lung fibrosis, diffusion
disturbance and arterial stiffness among patients with chronic hypersensitivity pneumonitis.
Biography
Elena Leonova PhD is a researcher of the Department of differential diagnosis of Interstitial lung diseases (Federal Central Tuberculosis
Research Institute). After defending her dissertation on clinical and functional characteristics of patients with COPD and atrial fibrillation,
she has focused on studying cardiovascular problems among patients with interstitial lung diseases.
Elena Leonova, J Clinical Diagnosis and Treatment, Volume 2