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Volume 3
Journal of Neurology and Clinical Neuroscience
Neurology 2019 | Neuropsychology 2019 | Drug Delivery Summit 2019
June 24-25, 2019
June 24-25, 2019 | Rome, Italy
Neurology and Healthcare
3
rd
WorldDrug Delivery and Formulations Summit
Clinical and Experimental Neuropsychology
4
th
International Conference on
International Conference on
&
Strategy of targeted pharmacological regulation of intracellular signal transduction in regenerative-
competent cells - A new direction of therapy in regenerative medicine
Gleb N Zyuz`kov
Russian Academy of Sciences, Russia
A
dvances in the field of cellular technologies have led to the possibility of developing a new direction of targeted
therapy in regenerative medicine - "Strategy of Pharmacological Regulation of Intracellular Signal Transduction
in Regenerator-competent Cells" (Patent RU № 2599289, 2016). The role of NF-кB, IKK, PKC, PKB, PI3K, ERK ½,
p38, adenylate cyclase, PKA, JAKs, STAT3, JNK, p53 in the realization of functioning progenitor elements of different
classes and cells of tissue microenvironment was studied in vitro by means of cultural, immunological and other methods.
On the models of posthypoxic encephalopathy, skin wound and cytostatic myelosuppression in experimental animals
the therapeutic effects and mechanisms of action of modifiers of signal molecules activity were studied. The specificity
of the involvement of a number of signaling molecules in the regulation of cell cycle and development of progenitor
cells of various classes, as well as in the production of humoral factors by microenvironment cells was revealed. The
neuroregenerative effects of JNK inhibitors associated with activation of neural stem cells of brain were shown on the
model of encephalopathy. An algorithm and approaches for estimating the potential efficiency and many-sided selectivity
of the modifiers of signaling molecules activity as targeted hemostimulators were developed. The effectiveness of
various targeted pharmacological agents determined by the selective effect on different types of regenerative-competent
cells was demonstrated on the models of cytostatic myelosuppression of various genesis. The perspective of using
intracellular signaling molecules in regenerative-competent cells as targets of drugs for regenerative medicine was shown.
Figure 1:
The participation of signaling molecules in the stimulation of proliferation multipotential mesenchymal stem cells. Simple arrows: intracellular
pathways involved in activation of functions of mesenchymal precursors under optimal vital activity; dotted arrows: pathways of suppression of mesenchymal
precursorcells;thickarrows: pathwaysofactivationfunctionsofmesenchymalprogenitorcellsundertheinfluenceofregulatoryfactors(redundantpathways).
J Neurol Clin Neurosci, Volume 3