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Volume 02
Journal of Immune Disorders & Therapy
J Immune Disord Ther, Volume 02
December 09-10, 2019 | Barcelona, Spain
9
th
WORLD CONGRESS ON
IMMUNOLOGY AND CANCER
World Immunology 2019 & Cancer Summit 2019
December 09-10, 2019
IL-10 mediated microvascular and epithelial perturbations in rejecting mouse airway
allografts
Mohammad Afzal Khan
King Faisal Specialist Hospital and Research Centre, KSA
M
icrovascular injuries during inflammation are key cause of transplant malfunctioning and permanent failure, which play
a major role in the development of chronic rejection of the transplanted organ. Inflammation induced microvascular loss
is a promising area to investigate the decisive roles of regulatory and effector responses. The present study was designed to
investigate the impact of IL-10 on immunotolerance, in particular, the microenvironment of the allograft during rejection.
Here, we investigated effects of IL-10 blockade/ reconstitution, and serially monitored regulatory T cells (Tregs), graft
microvasculature and airway epithelium in rejecting airway transplants.
We demonstrated that blocking/reconstitution of IL-10 significantly modulate CD4+FOXP3+ Tregs, microvasculature and airway
epithelium during rejection. Our findings further highlighted that blockade of IL-10 upregulated proinflammatory cytokines, IL-
2, IL-1β, IFN-γ, IL-15 and IL-23, but suppressed IL-5 secretion during rejection, however, reconstitution of IL-10 significantly
upregulated CD4+FOXP3+ Tregs, tissue oxygenation/blood flow and airway repair.
Collectively, these findings demonstrate a potential reparative modulation of IL-10 during microvascular and epithelial repair
which could provide a vital therapeutic window to rejecting transplants in clinical practice.
mkhan26@kfshrc.ede.sa