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Volume 02
Journal of Immune Disorders & Therapy
J Immune Disord Ther, Volume 02
December 09-10, 2019 | Barcelona, Spain
9
th
WORLD CONGRESS ON
IMMUNOLOGY AND CANCER
World Immunology 2019 & Cancer Summit 2019
December 09-10, 2019
Intelligent design, synthesis and validation of drug delivery systems targeted against
breast cancer stem cells
Petra Gener
Vall d’Hebron Research Institute, Spain
T
umor recurrence, metastatic spread and progressive gain of chemo-resistance of advanced cancers are sustained by the
presence of Cancer Stem Cells (CSCs) within the tumor. Targeted therapies with the aim to eradicate these cells are thus
highly regarded. However, often the use of new anti-cancer therapies is hampered by pharmacokinetic demands. Drug delivery
through nanoparticles has great potential to increase efficacy and reduce toxicity and adverse effects. However, its production
has to be based on intelligent design. Likewise, we developed polymeric nanoparticles loaded with Zileuton
TM
, a potent inhibitor
of Cancer Stem Cells (CSCs), which was chosen based on high throughput screening. Its great potential for CSCs treatment was
subsequently demonstrated in
in vitro
and in
in vivo
CSC fluorescent models. Encapsulated Zileuton
TM
reduce amount of CSCs
within the tumor and effectively block the Circulating Tumor Cells (CTCs) in the blood stream and metastatic spread.
Biography
Petra Gener is currently a research scientist in Hospital Universitari Vall d'HebronVall d'Hebron Institut de Recerca, Spain. Her research
interest includes drug delivery and targeting against cancer.
petra.gener@vhir.org