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Volume 02
Journal of Immune Disorders & Therapy
J Immune Disord Ther, Volume 02
December 09-10, 2019 | Barcelona, Spain
9th WORLD CONGRESS ON
IMMUNOLOGY AND CANCER
World Immunology 2019 & Cancer Summit 2019
December 09-10, 2019
Eplet: A unique comrade with the finest expression in transplantation immunology
Nidheesh Roy T A
University of Calicut, India
Over the past two decades, organ transplantation procedures have become a potential milestone in the field of modern
medicine. Even though physiological barriers and technical limitations exist in the process of organ transplantation, the
therapeutic breakthroughs happened during the recent years has made this process a historic achievement. Human Leucocyte
Antigen (HLA) has been known for its complexity as well as its identity in becoming a protein fingerprint. The lack of a healthy
matching donor is one of the major problems faced during renal transplantation. Till this time, the question of what causes
graft rejection still possesses a multifaceted answer which leaves the clinicians confused. In general, allo-graft transplantation
causes strong immune reaction between a donor and the recipient as both the individuals possess sequentially different HLA.
Identification of a single molecular target between such protein complexes like HLA and T Cell Receptor (TCR) could be a
breakthrough in transplantation immunology. Use of high-throughput molecular simulation techniques or a highly established
protein docking binary systems might be of great use for clinicians as this can lead to reduction in the use of administration
of immunosuppressants. The traditional procedures incorporates direct complement depended cell cytotoxicity crossmatching
(CDC-cxm) and HLATyping which still possess its significance in transplantation medicine. Our aim relies on another perspective
which targets Eplets. Eplets are those amino acid triplet confirmations which are spatially adjacent but linearly discontinuous.
Epitope and Eplet matching has been a great part globally. The analysis of eplet matching after pinpointing the HLA ID of both
donor and recipient are performed molecularly as well as computationally. Therefore targeting the identification and matching
of each eplets between unrelated individuals may open new avenues in modern medicinal research. Analysis and calculation of
antibody–verified eplets can be used to predict the outcome of less matched allo-graft transplants. The method of protein-protein
docking can be also implemented to identify the hotspots in HLA which might cause such strong immune reactions.
Biography
Nidheesh Roy T. A, has earned appreciable skills in working with human cell lines, membrane protein isolation, CDC-CXM, HLA Typing,
HLA Matchmaker and Protein docking. He has acquired good knowledge in computational biology; have used various protein docking
softwares for studies related to the ongoing research work. Has a year of teaching experience for post graduate students, which include
topics related to both biotechnology as well as general knowledge. Have earned laboratory skills from working in two research labs,
microbiology and immunotechnology laboratory, as well as in a sophisticated transplantation immunology and molecular diagnostic
facility. Have published two papers as a result of the contributions provided to the previous laboratory. Have a great passion for
acquiring knowledge and new skills, effective time-management skills, flawless with computers, expert in Photoshop and Aftereffects,
confident level of skills in using OnShape-CAD and high enthusiasm in photography.