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Journal of Neurology and Clinical Neuroscience | Volume: 03
8th International Conference on
NEUROLOGICAL DISORDERS,
CENTRAL NERVOUS SYSTEM AND STROKE
&
International Conference on
NEUROLOGY AND NEUROSURGERY
December 04-05, Dubai, UAE
Joint event on J Neurol Clin Neurosci, Volume: 03
To study serummagnesium level in patient withMigraine and efficacy of combination
of folic acid and magnesium in treatment of Migraine
Shalin Shah
Artemis Institute, India
Background : Pathophysiology of migraine involves
different mechanisms including modulation of central
and peripheral pain structures and release of vasoactive
peptides. Studies revealed decreased levels of
micronutrients riboflavin, magnesium and coenzyme.
Deficit of nutrients could play role in the pathophysiology.
Treatment with nutritional supplement might benefit for
patients who cannot tolerate chemical drugs.
Methods : In this cross sectional analytical observational
study, Magnesium levels of 56 patient checked. Then
recruited into Folic acid + magnesium (FA+Mg) and
Flunarizine. Headache Impact Test (HIT) scorewas evaluated
pre and post treatment after 2 month. Concomitant
improvement and adverse events was checked.
Results : Mean magnesium was 1.9877 ± 0.1355 with
range between 1.65-2.34mg. 21.4 % had low magnesium.
Mean magnesium found in lower normal range.Pre HIT
was between 56-66 with mean of 66.30. In FA+MG , 27
patients had Pre HIT of 64.93 ± 5.196 and in flunarizine , 29
patients had 67.59 ± 4.524.Comparison showed significant
difference (p value - 0.046).Post HIT in FA+MG was 53.81
± 10.340 and Flunarizine was 54.55 ± 8.919. Comparison
showed no statistical difference (p value - 0.776).
Comparing percentage difference with FA+MG having
17.0898 ± 14.79 and flunarizine having 18.7929 ± 15.3326
with no statistical differences ( p value - 0.674). Response
to treatment and Side effects showed no statistical
difference between both groups (p value - 0.685).
Conclusion: Hypomagnesemia would be one factor
causing migraine and should be checked in patients with
suspected migraine.Starting prophylaxis with Combination
of Folic acid and magnesium would be better.
Biography
Shalin Shah, has finished his DM neurology last year from prestigious
amrita institute of medical science , kochi, India. His mentor was Dr.
Anand kumar who is head of department in amrita institute. He had
done work and thesis of vascular headache. At present he is doing his
Stroke and neurointervention fellowship.
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