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Journal of Neurology and Clinical Neuroscience | Volume: 03
8th International Conference on
NEUROLOGICAL DISORDERS,
CENTRAL NERVOUS SYSTEM AND STROKE
&
International Conference on
NEUROLOGY AND NEUROSURGERY
December 04-05, Dubai, UAE
Joint event on J Neurol Clin Neurosci, Volume: 03
Advance and novel research technique used for the targeted release of anti tumor
drug to treat Glioblastoma tumors
Iram Khan
Jamia Hamdard University, India
Statement of the Problem: Glioblastoma is the most
frequently occurring and devastating primary brain tumor.
Treatments involved surgery followed by radiotherapy with
concomitant and adjuvant chemotherapy however faces
a primary hurdle in delivery of drug to BBB (blood brain
barrier) and has found insufficient penetration of drug
to attain a therapeutic effect. New strategies are highly
required with improvised and innovative technology such
as a degradable delivery device that provides targeted
multiple adjuvant chemotherapeutic agents to the target
site for the treatment of tumor. Adopting a nanotechnology
technique such as Electrospinning technique helps in
manufacturing of nanofibres and thus nanofiber based
Drug Delivery System (DDS) was designed for oral delivery
of anti-tumor drug in the cerebral cavity for an effective
treatment of Glioblastoma tumors.
Methodology & Theoretical Orientation: The study
involves fabrication of polymeric drug loaded nanofibres
using Electrospinning process. The prepared nanofibres
formulation were validated by various characterization
methods using FTIR and surface morphology by AFM, SEM,
TEM analysis, dug release, in-vitro are studied, cytotoxicity
of nanofibers was evaluated by MTT assay in U87 MG Brain
tumor cell line. In vivo antitumor efficacy of nanofibers
was evaluated in Albino Wistar Rats bearing tumors.
Findings: The formulations of nanofibers were well-
characterized and in vitro release and kinetic studies
suggest sustained release. The antitumor potential of the
polymeric drug loaded nanofibers were evaluated against
U87 MG Brain tumor cell line. In vivo antitumor efficacy
of nanofibers shows primary tumor resection decreased in
treated with oral administered nanofibers, compared with
the blank nanofibres, systemic or locally administered drug
and the control group.
Conclusion & Significance: The experimental result shows
that the biodegradable nanofibres are having high drug
loading efficiency and drug releasing efficiency after oral
formulation in rats showing excellent biocompatibility, and
results obtained reveals adopting drug eluting nanofibres
may result in sustain delivery of anti-tumor drug in the
cerebral cavity in order to attain enhanced therapeutic
effect.
Biography
Iram Khan has completed her M.Pharm in Quality Assurance and was
declared Gold Medalist for her B.Pharm from Uttar Pardesh Technical
University. She is currently pursuing her PhD from Jamia Hamdard,
New Delhi in Pharmaceutics Specialization in Quality Assurance under
supervision of Prof. (Dr.) Yasmin Sultana. She has published book
chapters and papers in journals and has presented many papers and
attended various seminars and conferences.
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