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Microbiol Biotechnol Rep | Volume 1, Issue 2
November 16-17, 2017 Atlanta, Georgia, USA
Annual Congress on
Mycology and Fungal Infections
Review of species distribution and susceptibility of invasive isolates of
Candida spp
as evaluated using the previous and recently revised clinical breakpoints and method
dependent epidemiological cut of values
A Serda Kantarcioğlu
Istanbul University, Turkey
I
nvasive
Candida
infections often cause high morbidity and mortality especially in the critically ill or
immunosuppressive patients. Although
Candida
albicans
was the most frequently isolated species as the
causative agent of
Candida
infections, geographical differences and changes over time in the species distribution
and the susceptibility to antifungals were reported in several surveillance programs. Some variations have been
shown to occur among institutions, localities, or countries. It is significant to determine the species distribution and
antifungal resistance in large medical centers. We reviewed the species distribution and antifungal susceptibility
data of 1371 invasive
Candida
strains isolated in a large university hospital mycology laboratory over 16 years.
Susceptibility tests against amphotericin B and azoles were routinely performed using Clinical and Laboratory
Standards Institute guidelines from 1998 to 2012 and using Etest from 2012 to 2014. The Sensititre YeastOne
colorimetric method was used to test
Candida
echinocandin susceptibility between 2012 and 2014. All test
results were routinely reported to clinicians. In this retrospective analysis, resistance or non-wild type phenotypes
to systemic antifungals were determined by the previous and recently revised CLSI breakpoints (BPs) and by
method dependent species-specific epidemiological cutoff values respectively. The new epidemiological BPs
provided by CLSI changed the percentage of resistant
C.
albicans
,
C. parapsilosis
and particularly
C. tropicalis
isolates to fluconazole.
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