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Volume 02

Stem Cells 2019 & Pediatrics Congress 2019

November 06-07, 2019

Journal of Clinical Genetics and Genomics

November 06-07, 2019 | Tokyo, Japan

STEM CELLS AND REGENERATIVE MEDICINE

PEDIATRICS AND CHILD CARE

International Conference on

2

nd

World Congress on

&

J Clin Gen Genomics, Volume 02

Electrophoretic deposition and characteristics of chitosan/AgNPs coatings on the

Ti13Zr13Nb alloy

Lukasz Pawlowski

Gdansk University of Technology, Poland

Introduction

: The surface of materials intended for implants is modified, among others to improve their biocompatibility

and providing protection against bacteria. It is important to provide long-term protection against bacterial colonization, hence

intensive work on the production of coatings that will release the drug substance in a controlled manner. Chitosan belongs to

the group of so-called "intelligent" biopolymers, because it reacts to pH changes. Chitosan coatings can therefore be a matrix

that will release the drug substance when the inflammation occurs, which is associated with a decrease in the pH value of the

environment of peri-implant tissues.

Methodology

: As part of this work, chitosan coatings with silver nanoparticles were produced by electrophoretic method

on the surface of the Ti-13Zr-13Nb titanium alloy, previously anodized electrochemically to obtain a nanotube oxide layer.

Microstructure, morphology and phase composition were examined with scanning electron microscopy and X-ray diffractometer.

The mechanical behavior was studied by nanoindentation and nanoscratch tests. The silver dissolution rate in simulated body

fluid was measured with atomic absorption spectrometry.

Results

: The produced nanotubes were highly ordered. The average diameter of nanotubes was about 40 nm, while their

length - about 1 μm. The obtained composite coatings were characterized by high homogeneity, silver nanoparticles were quite

evenly distributed in the coating, however, they tended to form agglomerates.

Mechanical tests showed that the coatings are characterized by relatively high

values of parameters such as: hardness and Young's modulus, (1.24 ± 0.16) GPa

and (52.29 ± 3.73) GPa respectively. The adhesion of the coatings to the substrate

was also satisfactory. The mean value of the critical force resulting in the total

removal of the composite coating from the substrate was (155.03 ± 29.89) mN.

The concentration of released silver reached a level sufficient to combat bacteria.

Biography

Lukasz Pawlowski is PhD student at Gdansk University of Technology, Department of Materials Engineering and Bonding, Biomaterials

Group, Poland. His doctoral thesis concerns surface modification of titanium alloys mainly by electrophoretic deposition of composite

coatings, which release drug substance in a controlled manner.

lukasz.pawlowski@pg.edu.pl

Figure 1. Graphical abstract