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Volume 02

Stem Cells 2019 & Pediatrics Congress 2019

November 06-07, 2019

Journal of Clinical Genetics and Genomics

November 06-07, 2019 | Tokyo, Japan

STEM CELLS AND REGENERATIVE MEDICINE

PEDIATRICS AND CHILD CARE

International Conference on

2

nd

World Congress on

&

J Clin Gen Genomics, Volume 02

Stem cell growth and differentiation factors from zebrafish embryo and their

role as epigenetic regulators in hair regeneration: Results after their transdermal

administration by cryopass laser treatment

Biava P M

Istituto di Ricovero e Cura a Carattere Scientifico Multimedica Milano, Italy

Introduction

: Previous studies, conducted over many years in our laboratories on zebrafish embryos, allowed the identification

of precise moments of stem cell differentiation in which a lot of genes switch on and off, a sign that the genome is undergoing

substantial changes in gene expression. The factors of the early developmental stage of zebrafish embryo were able to regulate the

stem cell expression of multipotency, enhancing the stemness genes Oct-4, Sox-2 and c-Myc. In addition to affecting stemness

genes which maintain stem cell identity, these factors taken in a primarily multiplicative stage also elicited transcriptional

activation of two major mechanisms capable of opposing stem cell senescence, including the gene expression of TERT, the

catalytic subunit of telomerase and the transcription of Bmi1, a Trithorax family of repressors which act as essential factors for

self-renewal of adult stem cells and as key telomerase-independent repressors of cell aging.

On the contrary, the molecules taken during differentiation events are able to reprogramming pathological stem cells. On the basis

of the researches about stem cell rejuvenation ad differentiation many studies were made. In the present study we present the

clinical results on twenty men aged between 46 and 67 (average age 57) with androgenetic alopecia. They were treated with stem

cell growth and differentiation factors from zebrafish embryo using cryopass-laser treatment for the transdermal administration.

The materials and methods to prepare the zebrafish extracts and about the use of cryopass laser were already described.

Results

: All the patients demonstrated an initial regeneration of hair in the form of a soft fleece after the first treatment. This

regeneration was consolidated with subsequent treatments and after about 10 treatments the hair took on a consistency of adult

and pigmented hair. The treatment did not have any adverse effect and was very well accepted by patients who were satisfied

with the obtained results.

Biography

Biava PM is author of many scientific publication and 8 books about reprogramming pathological and normal stem cell.

biava@tiscali.it

Figure 1. A patient before the treatment with stem cell

growth and differentiation factors

Figure 2. The same patient after the treatment