toxicology-2019-scientifictracks

Page 18

Volume 02

Clinical Pharmacology and Toxicology Research

Toxicology 2019

November 11-12, 2019

November 11-12, 2019 | London, UK

TOXICOLOGY AND CLINICAL TOXICOLOGY

International Conference on

Clin Pharmacol Toxicol Res, Volume 02

Prenatal exposure levels of Polybrominated diphenyl ethers in mother-infant pairs

and their transplacental transfer characteristics in Uganda (East Africa)

Patrick Ssebugere

Makerere University, Uganda

olybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants with adverse effects on the fetus and infants.

The aim of the present study was to assess in utero exposure levels

and transplacental transfer characteristics of BDE congeners in mothers

from Kampala capital city, Uganda. Paired human samples (thirty placenta

and twenty nine cord blood samples) were collected from mothers at St.

Francis Hospital Nsambya between April and June, 2018 and analysed

for a suite of 24 tri- to deca-BDE congeners. Extraction was carried out

using liquid-liquid extraction and sonication for cord blood and placenta

samples, respectively. Clean-up was done on a solid phase (SPE) column and analysis was performed using gas chromatography/

mass spectrometer (GC/MS). Total (∑) PBDEs were 0.25-30.9 ng/g lipid weight (lw), (median; 7.11 ng/g lw) in the placenta

and 1.65-34.5 ng/g lw (median; 11.9 ng/g lw) in cord blood serum. Statistical analysis showed no significant difference between

the levels of PBDEs in cord blood and placenta samples (Wilcoxon signed rank test: Z = -0.433, p = 0.665), possibly due to

poor xenophobic metabolism by the fetus. BDE-209 was the dominant congener in both matrices (contributed 40.5% and 51.2%

to ∑PBDEs in placenta and cord blood, respectively), suggesting on-going maternal exposure to deca-BDE formulation. No

apparent correlation was observed between BDE congeners and meat consumption probably due to multiple sources of PBDEs.

Based on absolute concentrations, the extent of transplacental transport (TPT) was high for higher congeners (BDE-209, 206 and

207) than for lower ones (such as BDE-47) suggesting alternative TPT mechanisms besides passive diffusion.

Biography

Patrick Ssebugere completed his

in Green Chemical Technology from Lappeenranta University of Technology in 2015. He is a

Lecturer of Physical Chemistry at the Department of Chemistry, School of Physical Sciences, Makerere University. He has published

more than 17 papers in reputed journals and has supervised more than 8 master’s students to completion. His research group is

involved in modeling and risk assessment of organic pollutants in the tropics. The group is also studying the prevalence and fate of

organic chemical contaminants in the environment, their sources and climate change-energy-public health nexus and sustainability of

ecosystems.