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Volume 02
Clinical Pharmacology and Toxicology Research
Toxicology 2019
November 11-12, 2019
November 11-12, 2019 | London, UK
TOXICOLOGY AND CLINICAL TOXICOLOGY
2
nd
International Conference on
Clin Pharmacol Toxicol Res, Volume 02
Variation in oxidative stress parameters after subchronic exposure to a Lambda
cyhalothrin pesticide in Wistar rats
Abderraouf Ayachi
University of Tebessa, Algeria
L
ambda cyhalothrin is a synthetic pyrethroid insecticide, which is increasingly used in agriculture and home pest control. Our
experimental study was carried out on 18 male WISTAR rats (Rattus rattus) divided into
three groups: group A (06 rats) control, group B (06 rats) treated with LCT (05 mg / kg / day),
group C (06 rats) treated with LCT (10 mg / kg / day) administered orally for 90 days The present
work involves the evaluation of the potential toxicity of LCT on the kidneys of rats and the
variation of some on oxidative stress parameters. The results obtained after the administration of
LCT show that it has caused a generally prooxidizing effect, this is revealed by the reduction of
the reduced glutathione level GSH and the enzymatic activity of the glutathione peroxidase GPx
and catalase CAT in the kidneys and also by increasing the enzymatic activity of glutathione-S-
transferase GST and the level of MDA in treated rats with different doses compared to controls.
All of these results are signs of possible nephrotoxicity.
Biography
Abderraouf Ayachi has a BA and MA in Applied Toxicology from the Faculty of Exact Sciences and Nature and Life Sciences, University
of Tebessa, Algeria as well as a Biologist in the Laboratory of the Mother and Child Hospital in Tebessa, Algeria. He has a great desire
to develop his knowledge in the field of scientific research and gain more experience.
e
:
raouf1794@gmail.comFigure: General presentation concludes
the nephrotoxic effects of Lambda
cyhalothrin on rat