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Page 25
Volume 2
July 24-25, 2019 | Rome, Italy
World Hematology 2019 & Nursing Care 2019
July 24-25, 2019
Journal of Blood Disorders and Treatment
47th WORLD CONGRESS ON NURSING CARE
11th WORLD HEMATOLOGY AND ONCOLOGY CONGRESS
&
The heart of the matter: A unique convergence of cardiac neoplasm, hereditary
nonpolyposis colorectal cancer, and spindle cell sarcoma
Emily Bryer DO, Lee Hartner
Pennsylvania Hospital University of Pennsylvania School of Medicine, USA
P rimary cardiac tumors are exceedingly unusual
and aggressive; they often develop in younger
patients and present with advanced disease. The
rarity and heterogeneity of primary cardiac tumors
challenge the standardization of therapeutic
guidelines. Undifferentiated primary cardiac spindle
cell sarcomas, a distinct subset of primary cardiac
sarcomas, are especially unique with fewer than 20
cases reported worldwide—the majority of which are
of left atrial origin. We present a review of the etiology,
pathophysiology, and therapy of undifferentiated
primary cardiac spindle cell sarcomas. In conjunction,
we present a unique case of a woman with hereditary
nonpolyposis colorectal cancer (Lynch syndrome) who
presented with a primary cardiac spindle cell sarcoma
of left ventricular origin, the first case of this type and location of cardiac tumor reported in a patient with Lynch syndrome. While
some malignancies are more common in patients with Lynch syndrome, sarcomas are not one of them. The absence of metastases
at the time of diagnosis is atypical for left-sided cardiac sarcomas, the overwhelming majority of which have metastases at the
time of diagnosis. In addition to anatomic and pathophysiologic distinctions of this case from other primary cardiac spindle cell
sarcomas, it also demonstrated unique immunohistochemistry as the first reported case of MDM-negative (murine double minute
homolog, a principle diagnostic marker of spindle cell sarcoma) ever reported.
Biography
Emily Bryer is a physician in Philadelphia, Pennsylvania USA. She attended the Schreyer Honors College of The Pennsylvania State
University for her undergraduate training where she served as President of Global Medical Brigades and established medical clinics in
areas of Ghana, Honduras, Nicaragua, and Panama with limited access to medical care and healthcare resources. She received her
medical degree from The Philadelphia College of Osteopathic Medicine before starting her Internal Medicine residency at Pennsylvania
Hospital of the University of Pennsylvania. Her research interests include venous thromboembolism in chemotherapy-induced anemia
and gestational trophoblastic disease.
J Blood Disord Treat, Volume 2
Left atrium
Left ventricle
Right atrium
Right ventricle
Pericardium
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