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Page 22
Volume 2
July 24-25, 2019 | Rome, Italy
World Hematology 2019 & Nursing Care 2019
July 24-25, 2019
Journal of Blood Disorders and Treatment
47th WORLD CONGRESS ON NURSING CARE
11th WORLD HEMATOLOGY AND ONCOLOGY CONGRESS
&
Cytogenetic profile of Philadelphia chromosome positive chronic myeloid leukemia
Nazia Hafeez, Ikramdin Ujjan
Liaquat University of Medical & Health Sciences, Pakistan
Chronic myeloid leukemia; a clonal hematopoietic stem cell
disorder characterized by a specific chromosomal translocation,
t (9;22), results in a shortened chromosome 22; The Philadelphia (Ph)
chromosome. Emergence of non-random chromosomal abnormalities
in addition to the Philadelphia chromosome is a well-recognized
event in CML and is referred to as clonal evolution. Detection of these
cytogenetic abnormalities is imperative in stratifying patients into
different prognostic groups and to offer appropriate treatment options.
The study aimed to analyze various other chromosomal abnormalities in
Philadelphia positive chronic myeloid leukemia patients.
Patients diagnosed as CML were included and cytogenetic studies were
performed with the conventional G-banding technique. A minimum of 20 metaphases were analyzed and described according
to the International System for Human Cytogenetic Nomenclature (ISCN) guidelines. The diagnosis of CML was based on
characteristic peripheral blood smear and bone marrow examination findings and was confirmed by presence of the Philadelphia
chromosome on bone marrow cytogenetic studies. Early identification of these abnormalities may help in adapting to a more
appropriate therapeutic approach. A risk stratification system based on prognostic relevance of individual ACAs may be a useful
guide to prognosticate and guide treatment of CML at diagnosis and clonal evolution.
Biography
Nazia Hafeez, currently working as a Chief Resident in Hematology Postgraduate Training FCPS II in a tertiary care hospital laboratory
in Hyderabad. We are looking forward to establish much more facilities as it’s much limited resources in this under privileged area
catering to mostly the poor communities.
J Blood Disord Treat, Volume 2