cancer-research-structural-biochemistry-2019-tracks

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Volume 3

August 5-6, 2019 | Singapore

CANCER RESEARCH AND PHARMACOLOGY

STRUCTURAL BIOCHEMISTRY, STEM CELLS AND MOLECULAR BIOLOGY

International Conference on

International Congress on

Cancer Research 2019 & Structural Biochemistry 2019

August 5-6, 2019

Journal of Cancer and Metastasis Research

Clin Psychol Cog Sci, Volume 3

Real-time potentiometric monitoring hydrolysis of a bio-degradable drug (Atracurium

besylate)

Ahmed Ma'mun

Cairo University, Egypt

ver the last decade, the field of Point-of-care (POC) diagnostics and

In- vitro

diagnostic (IVD) tests have been extensively

used and acquired increasing prominence. The outstanding opportunities offered have greatly expanded the application

fields and have placed these technologies at the forefront of the tests used in providing life-saving decisions to maintain health,

manage disease, monitor therapy or pre- surgical operation examinations. Being portable and the unique ability of selective, and

direct detection of ionic analytes in biological specimens without extraction, are very attractive features of potentiometric Ion

Selective Electrodes (ISEs). The ability to furnish a continuous real time signals allows performing

in vitro

monitoring of the

chemical species in chemical or biological reactions in the real time. Our drug, Atracurium besylate (ATR) is a skeletal muscle

relaxant used for anesthesia in surgical operations undergoes chemo-degradation

in vivo

yielding a toxic metabolite Laudanosine

(LDS). A closer insight to the

in vivo

metabolic processes of ATR, it was reported to be susceptible to degradation by Hofmann

elimination as a primary route and ester hydrolysis as a secondary route of chemo-degradation.

Biography

Ahmed Ma'mun he completed his master degree in analytical chemistry at Cairo university. Also, he is an Editorial board member in

journal of electrochemical society and many reputable scientific journals. Invited speaker in many international conferences worldwide.

Expert in all topics related to analytical chemistry and bioanalysis Since graduation from Faculty of pharmacy-Cairo university May

2006. This lecture is a part of my recent publication " Real-time potentiometric sensor; an innovative tool for monitoring hydrolysis

of chemo/bio-degradable drugs in pharmaceutical sciences" published in journal of biomedical and pharmaceutical analysis-The

American Chemical Society- February 2018.