cancer-research-structural-biochemistry-2019-tracks

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Volume 3

August 5-6, 2019 | Singapore

CANCER RESEARCH AND PHARMACOLOGY

STRUCTURAL BIOCHEMISTRY, STEM CELLS AND MOLECULAR BIOLOGY

International Conference on

International Congress on

Cancer Research 2019 & Structural Biochemistry 2019

August 5-6, 2019

Journal of Cancer and Metastasis Research

Bioinsilico analysis of c-MYC gene association with Burkitt’s Lymphoma

Enas Abdalla Mohammed Ahmedon

University of Khartoum, Sudan

Background

: MYC gene is an important proto-oncogene transcriptional factor encodes a nuclear phosphoprotein for central

cellular processes. Dysregulated expression or function of c-MYC is one of the most common abnormalities in human

malignancies. The normal c-MYC gene is encoded in three separate exons divided by two large intervening sequences in this

study we focused on detection of single nucleotide polymorphisms SNPs in MYC gene associated with formation of Burkitt’s

lymphoma, and to confirm or exclude most reported SNPs relationship with the disease, and detect novel mutations associated

with the disorder.

Materials and methods

: MYC gene was investigated in NCBI database

and SNPs were analysed

by computational softwares. SNPs in the coding region (exonal SNPs) that are non-synonymous (nsSNP) were analysed by (sift,

polyphen2, I-mutant, SNPs&GO and PHD-SNP softwares.

Result

: we analysed 2868 SNPs from(NCBI) 286 of them found in Homo sapiens,48 of them deleterious furtherly investigated.

Conclusion

: eight SNPs were considered most disease causing (rs4645959, rs4645959, rs141095253, rs141095253,

rs150308400, rs150308400, rs150308400, rs150308400) according to the four softwares used. Two ofwhich have not been

reported previously[rs4645959 (N25S), rs141095253 (P396L)].

Biography

Enas Abdalla Mohammed Ahmedon is a student. Currently pursuing her master’s in University of Khartoum, Sudan and she is interested in

hematology and immunohematology. She is good learner, interested in knowing, learning and developing skills, knowledge and competencies.

And she works as Scientist at Jafar IBin Auf Specialized Hospital for Children – Khartou.

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