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Volume 2
Journal of Clinical Diagnosis and Treatment
Annual Nephrology & Chronic Diseases 2019
May 20-21, 2019
Nephrology
Chronic Diseases
May 20-21, 2019 London, UK
19
th
Annual Conference on
3
rd
International Conference on
&
Incidence and prevalence of Parkinson’s Disease (PD) in Wales
Khalid Orayj
1
Arron Lacey
2
, Ashley Akbari
2
, Mathew Smith
1
, Owen Pickrell
2
and
Emma Lane
1
,
1
Cardiff University, United Kingdom
2
Swansea University Medical School, United Kingdom
Background:
Previous epidemiological studies in the UK have suggested a decline in the incidence of
Parkinson’s disease (PD) in recent years, accompanied by a relatively stable prevalence rate. Globally, there
seems to be variation in the trend of PD incidence and prevalence over time. A Welsh population-based study
is required to estimate the incidence and prevalence of PD in comparison to previous studies.
Methods:
Using the Secure Anonymised Information Linkage (SAIL) Databank, we conducted a population-
based study of residents in Wales, UK, aged 40 years or older between 2000 and 2016. The annual prevalence
and incidence of PD were estimated using the Read codes for PD diagnosis. Poisson regression was used to
estimate the incidence rate ratio (IRR) and prevalence risk ratio (PRR) across the study period.
Results:
We analysed 16,693,205 single person-years during 2000-2016. The incidence rate ranged from
54.74 to 68.04 per 100,000 person years across the study period. The incidence rate did not differ significantly
between the reference year (calendar year of 2000) and the majority of years of the study period (in 2016 the
IRR was 1.05 95% CI 0.93–1.18). However, the overall prevalence rate increased from 319.40 to 370.05 per
100,000 population between 2000 and 2016. The prevalence rate differed significantly between the reference
year and subsequent years (in 2016 the PRR was 1.16 95% CI 1.11–1.21).
Conclusions:
In Wales, the prevalence of PD has increased in the period between 2000 and 2016 with a
relatively stable incidence rate. This could be due to increasing population aging.
Orayjk@cardiff.ac.ukJ Clinical Diagnosis and Treatment, Volume 2